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Assessment of Antioxidant Capacity and Cytotoxicity of Selected Malaysian Plants
Thirteen Malaysian plants; Artocarpus champeden, Azadirachta indica, Fragaria x ananassa, Garcinia mangostana, Lawsonia inermis, Mangifera indica, Nephelium lappaceum, Nephelium mutobile, Peltophorum pterocarpum, Psidium guajava and Syzygium aqueum, selected for their use in traditional medicine, we...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257288/ https://www.ncbi.nlm.nih.gov/pubmed/20428033 http://dx.doi.org/10.3390/molecules15042139 |
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author | Ling, Lai Teng Radhakrishnan, Ammu Kutty Subramaniam, Thavamanithevi Cheng, Hwee Ming Palanisamy, Uma D. |
author_facet | Ling, Lai Teng Radhakrishnan, Ammu Kutty Subramaniam, Thavamanithevi Cheng, Hwee Ming Palanisamy, Uma D. |
author_sort | Ling, Lai Teng |
collection | PubMed |
description | Thirteen Malaysian plants; Artocarpus champeden, Azadirachta indica, Fragaria x ananassa, Garcinia mangostana, Lawsonia inermis, Mangifera indica, Nephelium lappaceum, Nephelium mutobile, Peltophorum pterocarpum, Psidium guajava and Syzygium aqueum, selected for their use in traditional medicine, were subjected to a variety of assays. Antioxidant capability, total phenolic content, elemental composition, as well as it cytotoxity to several cell lines of the aqueous and ethanolic extracts from different parts of these selected Malaysian plants were determined. In general, the ethanolic extracts were better free radical scavengers than the aqueous extracts and some of the tested extracts were even more potent than a commercial grape seed preparation. Similar results were seen in the lipid peroxidation inhibition studies. Our findings also showed a strong correlation of antioxidant activity with the total phenolic content. These extracts when tested for its heavy metals content, were found to be below permissible value for nutraceutical application. In addition, most of the extracts were found not cytotoxic to 3T3 and 4T1 cells at concentrations as high as 100 μg/mL. We conclude that although traditionally these plants are used in the aqueous form, its commercial preparation could be achieved using ethanol since a high total phenolic content and antioxidant activity is associated with this method of preparation. |
format | Online Article Text |
id | pubmed-6257288 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Molecular Diversity Preservation International |
record_format | MEDLINE/PubMed |
spelling | pubmed-62572882018-11-30 Assessment of Antioxidant Capacity and Cytotoxicity of Selected Malaysian Plants Ling, Lai Teng Radhakrishnan, Ammu Kutty Subramaniam, Thavamanithevi Cheng, Hwee Ming Palanisamy, Uma D. Molecules Article Thirteen Malaysian plants; Artocarpus champeden, Azadirachta indica, Fragaria x ananassa, Garcinia mangostana, Lawsonia inermis, Mangifera indica, Nephelium lappaceum, Nephelium mutobile, Peltophorum pterocarpum, Psidium guajava and Syzygium aqueum, selected for their use in traditional medicine, were subjected to a variety of assays. Antioxidant capability, total phenolic content, elemental composition, as well as it cytotoxity to several cell lines of the aqueous and ethanolic extracts from different parts of these selected Malaysian plants were determined. In general, the ethanolic extracts were better free radical scavengers than the aqueous extracts and some of the tested extracts were even more potent than a commercial grape seed preparation. Similar results were seen in the lipid peroxidation inhibition studies. Our findings also showed a strong correlation of antioxidant activity with the total phenolic content. These extracts when tested for its heavy metals content, were found to be below permissible value for nutraceutical application. In addition, most of the extracts were found not cytotoxic to 3T3 and 4T1 cells at concentrations as high as 100 μg/mL. We conclude that although traditionally these plants are used in the aqueous form, its commercial preparation could be achieved using ethanol since a high total phenolic content and antioxidant activity is associated with this method of preparation. Molecular Diversity Preservation International 2010-03-25 /pmc/articles/PMC6257288/ /pubmed/20428033 http://dx.doi.org/10.3390/molecules15042139 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Ling, Lai Teng Radhakrishnan, Ammu Kutty Subramaniam, Thavamanithevi Cheng, Hwee Ming Palanisamy, Uma D. Assessment of Antioxidant Capacity and Cytotoxicity of Selected Malaysian Plants |
title | Assessment of Antioxidant Capacity and Cytotoxicity of Selected Malaysian Plants |
title_full | Assessment of Antioxidant Capacity and Cytotoxicity of Selected Malaysian Plants |
title_fullStr | Assessment of Antioxidant Capacity and Cytotoxicity of Selected Malaysian Plants |
title_full_unstemmed | Assessment of Antioxidant Capacity and Cytotoxicity of Selected Malaysian Plants |
title_short | Assessment of Antioxidant Capacity and Cytotoxicity of Selected Malaysian Plants |
title_sort | assessment of antioxidant capacity and cytotoxicity of selected malaysian plants |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257288/ https://www.ncbi.nlm.nih.gov/pubmed/20428033 http://dx.doi.org/10.3390/molecules15042139 |
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