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Synthesis of Dihydrouracils Spiro-Fused to Pyrrolidines: Druglike Molecules Based on the 2-Arylethyl Amine Scaffold
The synthesis of a small library of dihydrouracils spiro-fused to pyrrolidines is described. These compounds are synthesized from β-aryl pyrrolidines, providing products with the 2-arylethyl amine moiety, a structural feature often encountered in compounds active in the central nervous system. The β...
Autores principales: | Blanco-Ania, Daniel, Valderas-Cortina, Carolina, Hermkens, Pedro H.H., Sliedregt, Leo A.J.M., Scheeren, Hans W., Rutjes, Floris P.J.T. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257290/ https://www.ncbi.nlm.nih.gov/pubmed/20428042 http://dx.doi.org/10.3390/molecules15042269 |
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