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Stereodynamic Investigation of Labile Stereogenic Centres in Dihydroartemisinin
Since its identification in the early 1970s, artemisinin, as well as semi-synthetic derivatives and synthetic trioxanes, have been used in malaria therapy. Reduction of artemisinin by NaBH(4) produced dihydroartemisinin (DHA), and yielded a new stereochemically labile centre at C-10, which, in turn,...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Molecular Diversity Preservation International
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257325/ https://www.ncbi.nlm.nih.gov/pubmed/20335983 http://dx.doi.org/10.3390/molecules15031309 |