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Glut1 and Glut3 as Potential Prognostic Markers for Oral Squamous Cell Carcinoma

We associated clinical-pathological features of 142 OSCC with the expression pattern of GLUT1 and GLUT3 in order to estimate their prognostic value. Methods: Clinical-pathological features and overall survival data of 142 patients with Oral Squamous Cell Carcinoma (OSCC) were retrospectively reviewe...

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Autores principales: Ayala, Fernanda Rocha Rojas, Rocha, Rafael Malagoli, Carvalho, Kátia Cândido, Carvalho, André Lopes, da Cunha, Isabela Werneck, Lourenço, Silvia Vanessa, Soares, Fernando Augusto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257354/
https://www.ncbi.nlm.nih.gov/pubmed/20428049
http://dx.doi.org/10.3390/molecules15042374
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author Ayala, Fernanda Rocha Rojas
Rocha, Rafael Malagoli
Carvalho, Kátia Cândido
Carvalho, André Lopes
da Cunha, Isabela Werneck
Lourenço, Silvia Vanessa
Soares, Fernando Augusto
author_facet Ayala, Fernanda Rocha Rojas
Rocha, Rafael Malagoli
Carvalho, Kátia Cândido
Carvalho, André Lopes
da Cunha, Isabela Werneck
Lourenço, Silvia Vanessa
Soares, Fernando Augusto
author_sort Ayala, Fernanda Rocha Rojas
collection PubMed
description We associated clinical-pathological features of 142 OSCC with the expression pattern of GLUT1 and GLUT3 in order to estimate their prognostic value. Methods: Clinical-pathological features and overall survival data of 142 patients with Oral Squamous Cell Carcinoma (OSCC) were retrospectively reviewed from A.C.Camargo hospital records. A tissue microarray (TMA) was built for the immunohistochemical (IHC) analysis of GLUT 1 and GLUT 3. IHC results were evaluated according to the staining pattern and number of positive cells. Results: GLUT 1 was over expressed in 50.3% of OSSC cases showing membrane staining pattern. However, nuclear expression was observed in 49.7% of the analyzed cases. GLUT 3 over expression was detected in 21.1% of OSCC cases. The pattern of GLUT 1 expression showed significant association with alcohol consumption (p = 0.004). Positive cell membrane GLUT 3 protein expression was associated with advanced clinic-staging of tumours (p = 0.005) as well as with vascular embolization (p = 0.005). Positive expression of GLUT 3 was associated with unfavorable free-disease survival (p = 0.021). Conclusion: GLUT1 and GLUT3 protein expression evaluated by immunohistochemistry are, significantly, indicators of poor prognosis outcome in oral squamous cell carcinoma, probably due to the enhanced glycolytic metabolism of more aggressive neoplastic cells.
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spelling pubmed-62573542018-11-30 Glut1 and Glut3 as Potential Prognostic Markers for Oral Squamous Cell Carcinoma Ayala, Fernanda Rocha Rojas Rocha, Rafael Malagoli Carvalho, Kátia Cândido Carvalho, André Lopes da Cunha, Isabela Werneck Lourenço, Silvia Vanessa Soares, Fernando Augusto Molecules Article We associated clinical-pathological features of 142 OSCC with the expression pattern of GLUT1 and GLUT3 in order to estimate their prognostic value. Methods: Clinical-pathological features and overall survival data of 142 patients with Oral Squamous Cell Carcinoma (OSCC) were retrospectively reviewed from A.C.Camargo hospital records. A tissue microarray (TMA) was built for the immunohistochemical (IHC) analysis of GLUT 1 and GLUT 3. IHC results were evaluated according to the staining pattern and number of positive cells. Results: GLUT 1 was over expressed in 50.3% of OSSC cases showing membrane staining pattern. However, nuclear expression was observed in 49.7% of the analyzed cases. GLUT 3 over expression was detected in 21.1% of OSCC cases. The pattern of GLUT 1 expression showed significant association with alcohol consumption (p = 0.004). Positive cell membrane GLUT 3 protein expression was associated with advanced clinic-staging of tumours (p = 0.005) as well as with vascular embolization (p = 0.005). Positive expression of GLUT 3 was associated with unfavorable free-disease survival (p = 0.021). Conclusion: GLUT1 and GLUT3 protein expression evaluated by immunohistochemistry are, significantly, indicators of poor prognosis outcome in oral squamous cell carcinoma, probably due to the enhanced glycolytic metabolism of more aggressive neoplastic cells. Molecular Diversity Preservation International 2010-04-01 /pmc/articles/PMC6257354/ /pubmed/20428049 http://dx.doi.org/10.3390/molecules15042374 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Ayala, Fernanda Rocha Rojas
Rocha, Rafael Malagoli
Carvalho, Kátia Cândido
Carvalho, André Lopes
da Cunha, Isabela Werneck
Lourenço, Silvia Vanessa
Soares, Fernando Augusto
Glut1 and Glut3 as Potential Prognostic Markers for Oral Squamous Cell Carcinoma
title Glut1 and Glut3 as Potential Prognostic Markers for Oral Squamous Cell Carcinoma
title_full Glut1 and Glut3 as Potential Prognostic Markers for Oral Squamous Cell Carcinoma
title_fullStr Glut1 and Glut3 as Potential Prognostic Markers for Oral Squamous Cell Carcinoma
title_full_unstemmed Glut1 and Glut3 as Potential Prognostic Markers for Oral Squamous Cell Carcinoma
title_short Glut1 and Glut3 as Potential Prognostic Markers for Oral Squamous Cell Carcinoma
title_sort glut1 and glut3 as potential prognostic markers for oral squamous cell carcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257354/
https://www.ncbi.nlm.nih.gov/pubmed/20428049
http://dx.doi.org/10.3390/molecules15042374
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