Synthesis and Biological Evaluation of New 5-Fluorouracil-Substituted Ampelopsin Derivatives

This study reports two novel 5-fluorouracil-substituted ampelopsin derivatives. The structures of two new derivatives were characterized by elemental analysis, (1)H-NMR, (13)C-NMR, IR and MS. Their anticancer activities in vitro against two cancer cell lines, K562 and K562/ADR, were investigated usi...

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Detalles Bibliográficos
Autores principales: Zhou, Wei-Ming, He, Rong-Rong, Ye, Jian-Tao, Zhang, Na, Liu, De-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257404/
https://www.ncbi.nlm.nih.gov/pubmed/20428031
http://dx.doi.org/10.3390/molecules15042114
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author Zhou, Wei-Ming
He, Rong-Rong
Ye, Jian-Tao
Zhang, Na
Liu, De-Yu
author_facet Zhou, Wei-Ming
He, Rong-Rong
Ye, Jian-Tao
Zhang, Na
Liu, De-Yu
author_sort Zhou, Wei-Ming
collection PubMed
description This study reports two novel 5-fluorouracil-substituted ampelopsin derivatives. The structures of two new derivatives were characterized by elemental analysis, (1)H-NMR, (13)C-NMR, IR and MS. Their anticancer activities in vitro against two cancer cell lines, K562 and K562/ADR, were investigated using the MTT assay, and the results showed that the two new compounds were more effective than reference drugs such as ampelopsin and verapamil.
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spelling pubmed-62574042018-11-30 Synthesis and Biological Evaluation of New 5-Fluorouracil-Substituted Ampelopsin Derivatives Zhou, Wei-Ming He, Rong-Rong Ye, Jian-Tao Zhang, Na Liu, De-Yu Molecules Article This study reports two novel 5-fluorouracil-substituted ampelopsin derivatives. The structures of two new derivatives were characterized by elemental analysis, (1)H-NMR, (13)C-NMR, IR and MS. Their anticancer activities in vitro against two cancer cell lines, K562 and K562/ADR, were investigated using the MTT assay, and the results showed that the two new compounds were more effective than reference drugs such as ampelopsin and verapamil. Molecular Diversity Preservation International 2010-03-24 /pmc/articles/PMC6257404/ /pubmed/20428031 http://dx.doi.org/10.3390/molecules15042114 Text en © 2010 by the authors; http://creativecommons.org/licenses/by/3.0/ licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Zhou, Wei-Ming
He, Rong-Rong
Ye, Jian-Tao
Zhang, Na
Liu, De-Yu
Synthesis and Biological Evaluation of New 5-Fluorouracil-Substituted Ampelopsin Derivatives
title Synthesis and Biological Evaluation of New 5-Fluorouracil-Substituted Ampelopsin Derivatives
title_full Synthesis and Biological Evaluation of New 5-Fluorouracil-Substituted Ampelopsin Derivatives
title_fullStr Synthesis and Biological Evaluation of New 5-Fluorouracil-Substituted Ampelopsin Derivatives
title_full_unstemmed Synthesis and Biological Evaluation of New 5-Fluorouracil-Substituted Ampelopsin Derivatives
title_short Synthesis and Biological Evaluation of New 5-Fluorouracil-Substituted Ampelopsin Derivatives
title_sort synthesis and biological evaluation of new 5-fluorouracil-substituted ampelopsin derivatives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257404/
https://www.ncbi.nlm.nih.gov/pubmed/20428031
http://dx.doi.org/10.3390/molecules15042114
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