Synthesis, Characterization and Biological Studies of Some Novel Thieno[2,3-d]pyrimidines

Several 2-unsubstituted thieno[2,3-d]pyrimidines have been prepared from 2-aminothiophene-3-carboxylic acid esters and their carbonitrile analogs. Some triazolo-thienopyrimidine and 2-thioxothienopyrimidine representatives have also been synthesized using thermal and microwave (MW) irradiation techn...

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Autores principales: Al-Taisan, Khulud M., Al-Hazimi, Hassan M. A., Al-Shihry, Shar S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257563/
https://www.ncbi.nlm.nih.gov/pubmed/20657418
http://dx.doi.org/10.3390/molecules15063932
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author Al-Taisan, Khulud M.
Al-Hazimi, Hassan M. A.
Al-Shihry, Shar S.
author_facet Al-Taisan, Khulud M.
Al-Hazimi, Hassan M. A.
Al-Shihry, Shar S.
author_sort Al-Taisan, Khulud M.
collection PubMed
description Several 2-unsubstituted thieno[2,3-d]pyrimidines have been prepared from 2-aminothiophene-3-carboxylic acid esters and their carbonitrile analogs. Some triazolo-thienopyrimidine and 2-thioxothienopyrimidine representatives have also been synthesized using thermal and microwave (MW) irradiation techniques. Structures of the prepared compounds were elucidated on the basis of IR, NMR, 2D NMR and mass spectral data. The biological activity of some selected synthesized compounds was also examined.
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spelling pubmed-62575632018-12-04 Synthesis, Characterization and Biological Studies of Some Novel Thieno[2,3-d]pyrimidines Al-Taisan, Khulud M. Al-Hazimi, Hassan M. A. Al-Shihry, Shar S. Molecules Article Several 2-unsubstituted thieno[2,3-d]pyrimidines have been prepared from 2-aminothiophene-3-carboxylic acid esters and their carbonitrile analogs. Some triazolo-thienopyrimidine and 2-thioxothienopyrimidine representatives have also been synthesized using thermal and microwave (MW) irradiation techniques. Structures of the prepared compounds were elucidated on the basis of IR, NMR, 2D NMR and mass spectral data. The biological activity of some selected synthesized compounds was also examined. MDPI 2010-06-01 /pmc/articles/PMC6257563/ /pubmed/20657418 http://dx.doi.org/10.3390/molecules15063932 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. This article is an Open Access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Al-Taisan, Khulud M.
Al-Hazimi, Hassan M. A.
Al-Shihry, Shar S.
Synthesis, Characterization and Biological Studies of Some Novel Thieno[2,3-d]pyrimidines
title Synthesis, Characterization and Biological Studies of Some Novel Thieno[2,3-d]pyrimidines
title_full Synthesis, Characterization and Biological Studies of Some Novel Thieno[2,3-d]pyrimidines
title_fullStr Synthesis, Characterization and Biological Studies of Some Novel Thieno[2,3-d]pyrimidines
title_full_unstemmed Synthesis, Characterization and Biological Studies of Some Novel Thieno[2,3-d]pyrimidines
title_short Synthesis, Characterization and Biological Studies of Some Novel Thieno[2,3-d]pyrimidines
title_sort synthesis, characterization and biological studies of some novel thieno[2,3-d]pyrimidines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257563/
https://www.ncbi.nlm.nih.gov/pubmed/20657418
http://dx.doi.org/10.3390/molecules15063932
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