Discovery and Structure–Activity-Relationship Study of N-Alkyl-5-hydroxypyrimidinone Carboxamides as Novel Antitubercular Agents Targeting Decaprenylphosphoryl-β-d-ribose 2′-Oxidase

[Image: see text] Magnesium plays an important role in infection with Mycobacterium tuberculosis (Mtb) as a signal of the extracellular environment, as a cofactor for many enzymes, and as a structural element in important macromolecules. Raltegravir, an antiretroviral drug that inhibits HIV-1 integr...

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Detalles Bibliográficos
Autores principales: Oh, Sangmi, Park, Yumi, Engelhart, Curtis A., Wallach, Joshua B., Schnappinger, Dirk, Arora, Kriti, Manikkam, Michelle, Gac, Brian, Wang, Hongwu, Murgolo, Nicholas, Olsen, David B., Goodwin, Michael, Sutphin, Michelle, Weiner, Danielle M., Via, Laura E., Boshoff, Helena I. M., Barry, Clifton E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257622/
https://www.ncbi.nlm.nih.gov/pubmed/30350998
http://dx.doi.org/10.1021/acs.jmedchem.8b00883

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