Cytotoxic Tirucallane Triterpenoids from Melia azedarach Fruits

The phytochemical investigation of the dichloromethane-soluble part of the methanol extract obtained from the fruits of Melia azedarach afforded one new tirucallane-type triterpene, 3-α-tigloylmelianol (1) and three known tirucallanes, melianone (2), 21-β-acetoxy-melianone (3), and methyl kulonate (...

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Detalles Bibliográficos
Autores principales: Ntalli, Nikoletta G., Cottiglia, Filippo, Bueno, Carlos A., Alché, Laura E., Leonti, Marco, Vargiu, Simona, Bifulco, Ersilia, Menkissoglu-Spiroudi, Urania, Caboni, Pierluigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257693/
https://www.ncbi.nlm.nih.gov/pubmed/20802401
http://dx.doi.org/10.3390/molecules15095866
Descripción
Sumario:The phytochemical investigation of the dichloromethane-soluble part of the methanol extract obtained from the fruits of Melia azedarach afforded one new tirucallane-type triterpene, 3-α-tigloylmelianol (1) and three known tirucallanes, melianone (2), 21-β-acetoxy-melianone (3), and methyl kulonate (4). The structure of the isolated compounds was mainly determined by 1D and 2D NMR experiments as well as HPLC-Q-TOF mass spectrometry. The cytotoxicity of the isolated compounds toward the human lung adenocarcinoma epithelial cell line A549 was determined, while no activity was observed against the phytonematode Meloidogyne incognita.

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