Cytotoxic Tirucallane Triterpenoids from Melia azedarach Fruits

The phytochemical investigation of the dichloromethane-soluble part of the methanol extract obtained from the fruits of Melia azedarach afforded one new tirucallane-type triterpene, 3-α-tigloylmelianol (1) and three known tirucallanes, melianone (2), 21-β-acetoxy-melianone (3), and methyl kulonate (...

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Autores principales: Ntalli, Nikoletta G., Cottiglia, Filippo, Bueno, Carlos A., Alché, Laura E., Leonti, Marco, Vargiu, Simona, Bifulco, Ersilia, Menkissoglu-Spiroudi, Urania, Caboni, Pierluigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257693/
https://www.ncbi.nlm.nih.gov/pubmed/20802401
http://dx.doi.org/10.3390/molecules15095866
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author Ntalli, Nikoletta G.
Cottiglia, Filippo
Bueno, Carlos A.
Alché, Laura E.
Leonti, Marco
Vargiu, Simona
Bifulco, Ersilia
Menkissoglu-Spiroudi, Urania
Caboni, Pierluigi
author_facet Ntalli, Nikoletta G.
Cottiglia, Filippo
Bueno, Carlos A.
Alché, Laura E.
Leonti, Marco
Vargiu, Simona
Bifulco, Ersilia
Menkissoglu-Spiroudi, Urania
Caboni, Pierluigi
author_sort Ntalli, Nikoletta G.
collection PubMed
description The phytochemical investigation of the dichloromethane-soluble part of the methanol extract obtained from the fruits of Melia azedarach afforded one new tirucallane-type triterpene, 3-α-tigloylmelianol (1) and three known tirucallanes, melianone (2), 21-β-acetoxy-melianone (3), and methyl kulonate (4). The structure of the isolated compounds was mainly determined by 1D and 2D NMR experiments as well as HPLC-Q-TOF mass spectrometry. The cytotoxicity of the isolated compounds toward the human lung adenocarcinoma epithelial cell line A549 was determined, while no activity was observed against the phytonematode Meloidogyne incognita.
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spelling pubmed-62576932018-12-06 Cytotoxic Tirucallane Triterpenoids from Melia azedarach Fruits Ntalli, Nikoletta G. Cottiglia, Filippo Bueno, Carlos A. Alché, Laura E. Leonti, Marco Vargiu, Simona Bifulco, Ersilia Menkissoglu-Spiroudi, Urania Caboni, Pierluigi Molecules Article The phytochemical investigation of the dichloromethane-soluble part of the methanol extract obtained from the fruits of Melia azedarach afforded one new tirucallane-type triterpene, 3-α-tigloylmelianol (1) and three known tirucallanes, melianone (2), 21-β-acetoxy-melianone (3), and methyl kulonate (4). The structure of the isolated compounds was mainly determined by 1D and 2D NMR experiments as well as HPLC-Q-TOF mass spectrometry. The cytotoxicity of the isolated compounds toward the human lung adenocarcinoma epithelial cell line A549 was determined, while no activity was observed against the phytonematode Meloidogyne incognita. MDPI 2010-08-27 /pmc/articles/PMC6257693/ /pubmed/20802401 http://dx.doi.org/10.3390/molecules15095866 Text en © 2010 by the authors; http://creativecommons.org/licenses/by/3.0/ licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Ntalli, Nikoletta G.
Cottiglia, Filippo
Bueno, Carlos A.
Alché, Laura E.
Leonti, Marco
Vargiu, Simona
Bifulco, Ersilia
Menkissoglu-Spiroudi, Urania
Caboni, Pierluigi
Cytotoxic Tirucallane Triterpenoids from Melia azedarach Fruits
title Cytotoxic Tirucallane Triterpenoids from Melia azedarach Fruits
title_full Cytotoxic Tirucallane Triterpenoids from Melia azedarach Fruits
title_fullStr Cytotoxic Tirucallane Triterpenoids from Melia azedarach Fruits
title_full_unstemmed Cytotoxic Tirucallane Triterpenoids from Melia azedarach Fruits
title_short Cytotoxic Tirucallane Triterpenoids from Melia azedarach Fruits
title_sort cytotoxic tirucallane triterpenoids from melia azedarach fruits
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257693/
https://www.ncbi.nlm.nih.gov/pubmed/20802401
http://dx.doi.org/10.3390/molecules15095866
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