Synthesis of [4-(2-Hydroxyphenyl)thiazol-2-yl]methanones as Potential Bioisosteres of Salicylidene Acylhydrazides

A focused library of [4-(2-hydroxyphenyl)thiazol-2-yl]methanones was prepared in a four-step synthesis with the aim to obtain potent inhibitors of type III secretion in Gram-negative bacteria. The compounds are potential bioisosteres of salicylidene acylhydrazides that are a known class of type III...

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Detalles Bibliográficos
Autores principales: Hillgren, J. Mikael, Dahlgren, Markus K., To, Tam M., Elofsson, Mikael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257736/
https://www.ncbi.nlm.nih.gov/pubmed/20877207
http://dx.doi.org/10.3390/molecules15096019
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author Hillgren, J. Mikael
Dahlgren, Markus K.
To, Tam M.
Elofsson, Mikael
author_facet Hillgren, J. Mikael
Dahlgren, Markus K.
To, Tam M.
Elofsson, Mikael
author_sort Hillgren, J. Mikael
collection PubMed
description A focused library of [4-(2-hydroxyphenyl)thiazol-2-yl]methanones was prepared in a four-step synthesis with the aim to obtain potent inhibitors of type III secretion in Gram-negative bacteria. The compounds are potential bioisosteres of salicylidene acylhydrazides that are a known class of type III secretion inhibitors.
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spelling pubmed-62577362018-12-06 Synthesis of [4-(2-Hydroxyphenyl)thiazol-2-yl]methanones as Potential Bioisosteres of Salicylidene Acylhydrazides Hillgren, J. Mikael Dahlgren, Markus K. To, Tam M. Elofsson, Mikael Molecules Article A focused library of [4-(2-hydroxyphenyl)thiazol-2-yl]methanones was prepared in a four-step synthesis with the aim to obtain potent inhibitors of type III secretion in Gram-negative bacteria. The compounds are potential bioisosteres of salicylidene acylhydrazides that are a known class of type III secretion inhibitors. MDPI 2010-08-31 /pmc/articles/PMC6257736/ /pubmed/20877207 http://dx.doi.org/10.3390/molecules15096019 Text en © 2010 by the authors; http://creativecommons.org/licenses/by/3.0/ licensee MDPI, Basel, Switzerland. This article is an Open Access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Hillgren, J. Mikael
Dahlgren, Markus K.
To, Tam M.
Elofsson, Mikael
Synthesis of [4-(2-Hydroxyphenyl)thiazol-2-yl]methanones as Potential Bioisosteres of Salicylidene Acylhydrazides
title Synthesis of [4-(2-Hydroxyphenyl)thiazol-2-yl]methanones as Potential Bioisosteres of Salicylidene Acylhydrazides
title_full Synthesis of [4-(2-Hydroxyphenyl)thiazol-2-yl]methanones as Potential Bioisosteres of Salicylidene Acylhydrazides
title_fullStr Synthesis of [4-(2-Hydroxyphenyl)thiazol-2-yl]methanones as Potential Bioisosteres of Salicylidene Acylhydrazides
title_full_unstemmed Synthesis of [4-(2-Hydroxyphenyl)thiazol-2-yl]methanones as Potential Bioisosteres of Salicylidene Acylhydrazides
title_short Synthesis of [4-(2-Hydroxyphenyl)thiazol-2-yl]methanones as Potential Bioisosteres of Salicylidene Acylhydrazides
title_sort synthesis of [4-(2-hydroxyphenyl)thiazol-2-yl]methanones as potential bioisosteres of salicylidene acylhydrazides
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257736/
https://www.ncbi.nlm.nih.gov/pubmed/20877207
http://dx.doi.org/10.3390/molecules15096019
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