Synthesis and Antifungal Activity of Carabrone Derivatives

Nine derivatives 6-14 of carabrone (1) were synthesized and tested in vitro against Colletotrichum lagenarium Ell et Halst using the spore germination method. Among all of the derivatives, compounds 6-8 and 12 showed more potent antifungal activity than 1. Structure-activity relationships (SAR) demo...

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Autores principales: Feng, Jun-Tao, Ma, Zhi-Qing, Li, Jiang-Hua, He, Jun, Xu, Hui, Zhang, Xing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257742/
https://www.ncbi.nlm.nih.gov/pubmed/20877238
http://dx.doi.org/10.3390/molecules15096485
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author Feng, Jun-Tao
Ma, Zhi-Qing
Li, Jiang-Hua
He, Jun
Xu, Hui
Zhang, Xing
author_facet Feng, Jun-Tao
Ma, Zhi-Qing
Li, Jiang-Hua
He, Jun
Xu, Hui
Zhang, Xing
author_sort Feng, Jun-Tao
collection PubMed
description Nine derivatives 6-14 of carabrone (1) were synthesized and tested in vitro against Colletotrichum lagenarium Ell et Halst using the spore germination method. Among all of the derivatives, compounds 6-8 and 12 showed more potent antifungal activity than 1. Structure-activity relationships (SAR) demonstrated that the γ-lactone was necessary for the antifungal activity of 1, and the substituents on the C-4 position of 1 could significantly affect the antifungal activity.
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spelling pubmed-62577422018-12-06 Synthesis and Antifungal Activity of Carabrone Derivatives Feng, Jun-Tao Ma, Zhi-Qing Li, Jiang-Hua He, Jun Xu, Hui Zhang, Xing Molecules Communication Nine derivatives 6-14 of carabrone (1) were synthesized and tested in vitro against Colletotrichum lagenarium Ell et Halst using the spore germination method. Among all of the derivatives, compounds 6-8 and 12 showed more potent antifungal activity than 1. Structure-activity relationships (SAR) demonstrated that the γ-lactone was necessary for the antifungal activity of 1, and the substituents on the C-4 position of 1 could significantly affect the antifungal activity. MDPI 2010-09-16 /pmc/articles/PMC6257742/ /pubmed/20877238 http://dx.doi.org/10.3390/molecules15096485 Text en © 2010 by the authors; http://creativecommons.org/licenses/by/3.0/ licensee MDPI, Basel, Switzerland. This article is an Open Access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Communication
Feng, Jun-Tao
Ma, Zhi-Qing
Li, Jiang-Hua
He, Jun
Xu, Hui
Zhang, Xing
Synthesis and Antifungal Activity of Carabrone Derivatives
title Synthesis and Antifungal Activity of Carabrone Derivatives
title_full Synthesis and Antifungal Activity of Carabrone Derivatives
title_fullStr Synthesis and Antifungal Activity of Carabrone Derivatives
title_full_unstemmed Synthesis and Antifungal Activity of Carabrone Derivatives
title_short Synthesis and Antifungal Activity of Carabrone Derivatives
title_sort synthesis and antifungal activity of carabrone derivatives
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257742/
https://www.ncbi.nlm.nih.gov/pubmed/20877238
http://dx.doi.org/10.3390/molecules15096485
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