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Kinin Receptor Antagonists as Potential Neuroprotective Agents in Central Nervous System Injury
Injury to the central nervous system initiates complex physiological, cellular and molecular processes that can result in neuronal cell death. Of interest to this review is the activation of the kinin family of neuropeptides, in particular bradykinin and substance P. These neuropeptides are known to...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257767/ https://www.ncbi.nlm.nih.gov/pubmed/20877247 http://dx.doi.org/10.3390/molecules15096598 |
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author | Thornton, Emma Ziebell, Jenna M Leonard, Anna V Vink, Robert |
author_facet | Thornton, Emma Ziebell, Jenna M Leonard, Anna V Vink, Robert |
author_sort | Thornton, Emma |
collection | PubMed |
description | Injury to the central nervous system initiates complex physiological, cellular and molecular processes that can result in neuronal cell death. Of interest to this review is the activation of the kinin family of neuropeptides, in particular bradykinin and substance P. These neuropeptides are known to have a potent pro-inflammatory role and can initiate neurogenic inflammation resulting in vasodilation, plasma extravasation and the subsequent development of edema. As inflammation and edema play an integral role in the progressive secondary injury that causes neurological deficits, this review critically examines kinin receptor antagonists as a potential neuroprotective intervention for acute brain injury, and more specifically, traumatic brain and spinal cord injury and stroke. |
format | Online Article Text |
id | pubmed-6257767 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62577672018-12-06 Kinin Receptor Antagonists as Potential Neuroprotective Agents in Central Nervous System Injury Thornton, Emma Ziebell, Jenna M Leonard, Anna V Vink, Robert Molecules Review Injury to the central nervous system initiates complex physiological, cellular and molecular processes that can result in neuronal cell death. Of interest to this review is the activation of the kinin family of neuropeptides, in particular bradykinin and substance P. These neuropeptides are known to have a potent pro-inflammatory role and can initiate neurogenic inflammation resulting in vasodilation, plasma extravasation and the subsequent development of edema. As inflammation and edema play an integral role in the progressive secondary injury that causes neurological deficits, this review critically examines kinin receptor antagonists as a potential neuroprotective intervention for acute brain injury, and more specifically, traumatic brain and spinal cord injury and stroke. MDPI 2010-09-20 /pmc/articles/PMC6257767/ /pubmed/20877247 http://dx.doi.org/10.3390/molecules15096598 Text en © 2010 by the authors; http://creativecommons.org/licenses/by/3.0/ licensee MDPI, Basel, Switzerland. This article is an Open Access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Thornton, Emma Ziebell, Jenna M Leonard, Anna V Vink, Robert Kinin Receptor Antagonists as Potential Neuroprotective Agents in Central Nervous System Injury |
title | Kinin Receptor Antagonists as Potential Neuroprotective Agents in Central Nervous System Injury |
title_full | Kinin Receptor Antagonists as Potential Neuroprotective Agents in Central Nervous System Injury |
title_fullStr | Kinin Receptor Antagonists as Potential Neuroprotective Agents in Central Nervous System Injury |
title_full_unstemmed | Kinin Receptor Antagonists as Potential Neuroprotective Agents in Central Nervous System Injury |
title_short | Kinin Receptor Antagonists as Potential Neuroprotective Agents in Central Nervous System Injury |
title_sort | kinin receptor antagonists as potential neuroprotective agents in central nervous system injury |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257767/ https://www.ncbi.nlm.nih.gov/pubmed/20877247 http://dx.doi.org/10.3390/molecules15096598 |
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