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Kinin Receptor Antagonists as Potential Neuroprotective Agents in Central Nervous System Injury

Injury to the central nervous system initiates complex physiological, cellular and molecular processes that can result in neuronal cell death. Of interest to this review is the activation of the kinin family of neuropeptides, in particular bradykinin and substance P. These neuropeptides are known to...

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Autores principales: Thornton, Emma, Ziebell, Jenna M, Leonard, Anna V, Vink, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257767/
https://www.ncbi.nlm.nih.gov/pubmed/20877247
http://dx.doi.org/10.3390/molecules15096598
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author Thornton, Emma
Ziebell, Jenna M
Leonard, Anna V
Vink, Robert
author_facet Thornton, Emma
Ziebell, Jenna M
Leonard, Anna V
Vink, Robert
author_sort Thornton, Emma
collection PubMed
description Injury to the central nervous system initiates complex physiological, cellular and molecular processes that can result in neuronal cell death. Of interest to this review is the activation of the kinin family of neuropeptides, in particular bradykinin and substance P. These neuropeptides are known to have a potent pro-inflammatory role and can initiate neurogenic inflammation resulting in vasodilation, plasma extravasation and the subsequent development of edema. As inflammation and edema play an integral role in the progressive secondary injury that causes neurological deficits, this review critically examines kinin receptor antagonists as a potential neuroprotective intervention for acute brain injury, and more specifically, traumatic brain and spinal cord injury and stroke.
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spelling pubmed-62577672018-12-06 Kinin Receptor Antagonists as Potential Neuroprotective Agents in Central Nervous System Injury Thornton, Emma Ziebell, Jenna M Leonard, Anna V Vink, Robert Molecules Review Injury to the central nervous system initiates complex physiological, cellular and molecular processes that can result in neuronal cell death. Of interest to this review is the activation of the kinin family of neuropeptides, in particular bradykinin and substance P. These neuropeptides are known to have a potent pro-inflammatory role and can initiate neurogenic inflammation resulting in vasodilation, plasma extravasation and the subsequent development of edema. As inflammation and edema play an integral role in the progressive secondary injury that causes neurological deficits, this review critically examines kinin receptor antagonists as a potential neuroprotective intervention for acute brain injury, and more specifically, traumatic brain and spinal cord injury and stroke. MDPI 2010-09-20 /pmc/articles/PMC6257767/ /pubmed/20877247 http://dx.doi.org/10.3390/molecules15096598 Text en © 2010 by the authors; http://creativecommons.org/licenses/by/3.0/ licensee MDPI, Basel, Switzerland. This article is an Open Access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Thornton, Emma
Ziebell, Jenna M
Leonard, Anna V
Vink, Robert
Kinin Receptor Antagonists as Potential Neuroprotective Agents in Central Nervous System Injury
title Kinin Receptor Antagonists as Potential Neuroprotective Agents in Central Nervous System Injury
title_full Kinin Receptor Antagonists as Potential Neuroprotective Agents in Central Nervous System Injury
title_fullStr Kinin Receptor Antagonists as Potential Neuroprotective Agents in Central Nervous System Injury
title_full_unstemmed Kinin Receptor Antagonists as Potential Neuroprotective Agents in Central Nervous System Injury
title_short Kinin Receptor Antagonists as Potential Neuroprotective Agents in Central Nervous System Injury
title_sort kinin receptor antagonists as potential neuroprotective agents in central nervous system injury
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257767/
https://www.ncbi.nlm.nih.gov/pubmed/20877247
http://dx.doi.org/10.3390/molecules15096598
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