Asymmetric Synthesis of α-Aminophosphonates Using the Inexpensive Chiral Catalyst 1,1’-Binaphthol Phosphate

Asymmetric addition under mild conditions of dialkyl phosphites on aldimines derived from cinnamaldehyde catalyzed by the inexpensive chiral organocatalyst (R)-3,3’-[4-fluorophenyl](2)-1,1’-binaphthol phosphate has been found effective to give new α-amino-phosphonates 9 in moderate yields (30–65%) a...

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Detalles Bibliográficos
Autores principales: Xu, Weiming, Zhang, Sha, Yang, Song, Jin, Lin-Hong, Bhadury, Pinaki S., Hu, De-Yu, Zhang, Yuping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257785/
https://www.ncbi.nlm.nih.gov/pubmed/20736906
http://dx.doi.org/10.3390/molecules15085782
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author Xu, Weiming
Zhang, Sha
Yang, Song
Jin, Lin-Hong
Bhadury, Pinaki S.
Hu, De-Yu
Zhang, Yuping
author_facet Xu, Weiming
Zhang, Sha
Yang, Song
Jin, Lin-Hong
Bhadury, Pinaki S.
Hu, De-Yu
Zhang, Yuping
author_sort Xu, Weiming
collection PubMed
description Asymmetric addition under mild conditions of dialkyl phosphites on aldimines derived from cinnamaldehyde catalyzed by the inexpensive chiral organocatalyst (R)-3,3’-[4-fluorophenyl](2)-1,1’-binaphthol phosphate has been found effective to give new α-amino-phosphonates 9 in moderate yields (30–65%) and enantiomeric excess (8.4%–61.9%).
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spelling pubmed-62577852018-12-06 Asymmetric Synthesis of α-Aminophosphonates Using the Inexpensive Chiral Catalyst 1,1’-Binaphthol Phosphate Xu, Weiming Zhang, Sha Yang, Song Jin, Lin-Hong Bhadury, Pinaki S. Hu, De-Yu Zhang, Yuping Molecules Article Asymmetric addition under mild conditions of dialkyl phosphites on aldimines derived from cinnamaldehyde catalyzed by the inexpensive chiral organocatalyst (R)-3,3’-[4-fluorophenyl](2)-1,1’-binaphthol phosphate has been found effective to give new α-amino-phosphonates 9 in moderate yields (30–65%) and enantiomeric excess (8.4%–61.9%). MDPI 2010-08-24 /pmc/articles/PMC6257785/ /pubmed/20736906 http://dx.doi.org/10.3390/molecules15085782 Text en © 2010 by the authors; http://creativecommons.org/licenses/by/3.0/ licensee MDPI, Basel, Switzerland. This article is an Open Access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Xu, Weiming
Zhang, Sha
Yang, Song
Jin, Lin-Hong
Bhadury, Pinaki S.
Hu, De-Yu
Zhang, Yuping
Asymmetric Synthesis of α-Aminophosphonates Using the Inexpensive Chiral Catalyst 1,1’-Binaphthol Phosphate
title Asymmetric Synthesis of α-Aminophosphonates Using the Inexpensive Chiral Catalyst 1,1’-Binaphthol Phosphate
title_full Asymmetric Synthesis of α-Aminophosphonates Using the Inexpensive Chiral Catalyst 1,1’-Binaphthol Phosphate
title_fullStr Asymmetric Synthesis of α-Aminophosphonates Using the Inexpensive Chiral Catalyst 1,1’-Binaphthol Phosphate
title_full_unstemmed Asymmetric Synthesis of α-Aminophosphonates Using the Inexpensive Chiral Catalyst 1,1’-Binaphthol Phosphate
title_short Asymmetric Synthesis of α-Aminophosphonates Using the Inexpensive Chiral Catalyst 1,1’-Binaphthol Phosphate
title_sort asymmetric synthesis of α-aminophosphonates using the inexpensive chiral catalyst 1,1’-binaphthol phosphate
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257785/
https://www.ncbi.nlm.nih.gov/pubmed/20736906
http://dx.doi.org/10.3390/molecules15085782
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