A Facile Synthesis of 3-Substituted 9H-Pyrido[3,4-b]indol-1(2H)-one Derivatives from 3-Substituted β-Carbolines

A mild and efficient two-step synthesis of 3-substituted β-carbolinone derivatives from 3-substituted β-carboline in good yields is described. A possible reaction mechanism for the formation of the skeleton of β-carbolin-1-one is proposed. The structures of these compounds were established by IR, (1...

Descripción completa

Detalles Bibliográficos
Autores principales: Lin, Guowu, Wang, Yue, Zhou, Qingfa, Tang, Weifang, Wang, Jian, Lu, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257788/
https://www.ncbi.nlm.nih.gov/pubmed/20717074
http://dx.doi.org/10.3390/molecules15085680
_version_ 1783374392266326016
author Lin, Guowu
Wang, Yue
Zhou, Qingfa
Tang, Weifang
Wang, Jian
Lu, Tao
author_facet Lin, Guowu
Wang, Yue
Zhou, Qingfa
Tang, Weifang
Wang, Jian
Lu, Tao
author_sort Lin, Guowu
collection PubMed
description A mild and efficient two-step synthesis of 3-substituted β-carbolinone derivatives from 3-substituted β-carboline in good yields is described. A possible reaction mechanism for the formation of the skeleton of β-carbolin-1-one is proposed. The structures of these compounds were established by IR, (1)H-NMR, (1)(3)C-NMR, mass spectrometry and elemental analysis, as well as X-ray crystallographic analysis of 4-2 and 6-2.
format Online
Article
Text
id pubmed-6257788
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62577882018-12-06 A Facile Synthesis of 3-Substituted 9H-Pyrido[3,4-b]indol-1(2H)-one Derivatives from 3-Substituted β-Carbolines Lin, Guowu Wang, Yue Zhou, Qingfa Tang, Weifang Wang, Jian Lu, Tao Molecules Article A mild and efficient two-step synthesis of 3-substituted β-carbolinone derivatives from 3-substituted β-carboline in good yields is described. A possible reaction mechanism for the formation of the skeleton of β-carbolin-1-one is proposed. The structures of these compounds were established by IR, (1)H-NMR, (1)(3)C-NMR, mass spectrometry and elemental analysis, as well as X-ray crystallographic analysis of 4-2 and 6-2. MDPI 2010-08-17 /pmc/articles/PMC6257788/ /pubmed/20717074 http://dx.doi.org/10.3390/molecules15085680 Text en © 2010 by the authors; http://creativecommons.org/licenses/by/3.0/ licensee MDPI, Basel, Switzerland. This article is an Open Access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Lin, Guowu
Wang, Yue
Zhou, Qingfa
Tang, Weifang
Wang, Jian
Lu, Tao
A Facile Synthesis of 3-Substituted 9H-Pyrido[3,4-b]indol-1(2H)-one Derivatives from 3-Substituted β-Carbolines
title A Facile Synthesis of 3-Substituted 9H-Pyrido[3,4-b]indol-1(2H)-one Derivatives from 3-Substituted β-Carbolines
title_full A Facile Synthesis of 3-Substituted 9H-Pyrido[3,4-b]indol-1(2H)-one Derivatives from 3-Substituted β-Carbolines
title_fullStr A Facile Synthesis of 3-Substituted 9H-Pyrido[3,4-b]indol-1(2H)-one Derivatives from 3-Substituted β-Carbolines
title_full_unstemmed A Facile Synthesis of 3-Substituted 9H-Pyrido[3,4-b]indol-1(2H)-one Derivatives from 3-Substituted β-Carbolines
title_short A Facile Synthesis of 3-Substituted 9H-Pyrido[3,4-b]indol-1(2H)-one Derivatives from 3-Substituted β-Carbolines
title_sort facile synthesis of 3-substituted 9h-pyrido[3,4-b]indol-1(2h)-one derivatives from 3-substituted β-carbolines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257788/
https://www.ncbi.nlm.nih.gov/pubmed/20717074
http://dx.doi.org/10.3390/molecules15085680
work_keys_str_mv AT linguowu afacilesynthesisof3substituted9hpyrido34bindol12honederivativesfrom3substitutedbcarbolines
AT wangyue afacilesynthesisof3substituted9hpyrido34bindol12honederivativesfrom3substitutedbcarbolines
AT zhouqingfa afacilesynthesisof3substituted9hpyrido34bindol12honederivativesfrom3substitutedbcarbolines
AT tangweifang afacilesynthesisof3substituted9hpyrido34bindol12honederivativesfrom3substitutedbcarbolines
AT wangjian afacilesynthesisof3substituted9hpyrido34bindol12honederivativesfrom3substitutedbcarbolines
AT lutao afacilesynthesisof3substituted9hpyrido34bindol12honederivativesfrom3substitutedbcarbolines
AT linguowu facilesynthesisof3substituted9hpyrido34bindol12honederivativesfrom3substitutedbcarbolines
AT wangyue facilesynthesisof3substituted9hpyrido34bindol12honederivativesfrom3substitutedbcarbolines
AT zhouqingfa facilesynthesisof3substituted9hpyrido34bindol12honederivativesfrom3substitutedbcarbolines
AT tangweifang facilesynthesisof3substituted9hpyrido34bindol12honederivativesfrom3substitutedbcarbolines
AT wangjian facilesynthesisof3substituted9hpyrido34bindol12honederivativesfrom3substitutedbcarbolines
AT lutao facilesynthesisof3substituted9hpyrido34bindol12honederivativesfrom3substitutedbcarbolines

Ejemplares similares