Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells

Cytokines and chemokines are produced and secreted by a broad range of immune cells including macrophages. Remarkably, little is known about how these inflammatory mediators are released from the various immune cells. Here, the endolysosomal cation channel TRPML2 is shown to play a direct role in ch...

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Detalles Bibliográficos
Autores principales: Plesch, Eva, Chen, Cheng-Chang, Butz, Elisabeth, Scotto Rosato, Anna, Krogsaeter, Einar K, Yinan, Hua, Bartel, Karin, Keller, Marco, Robaa, Dina, Teupser, Daniel, Holdt, Lesca M, Vollmar, Angelika M, Sippl, Wolfgang, Puertollano, Rosa, Medina, Diego, Biel, Martin, Wahl-Schott, Christian, Bracher, Franz, Grimm, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257821/
https://www.ncbi.nlm.nih.gov/pubmed/30479274
http://dx.doi.org/10.7554/eLife.39720

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