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The ins and outs of telomere crisis in cancer
Telomere crisis is linked with many of the genomic alterations found in cancer genomes. A new understanding of how these alterations arise points towards an active role for innate immune sensors during crisis and to new opportunities for the treatment and diagnosis of cancer.
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258172/ https://www.ncbi.nlm.nih.gov/pubmed/30482235 http://dx.doi.org/10.1186/s13073-018-0596-4 |
| _version_ | 1783374456322785280 |
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| author | von Morgen, Patrick Maciejowski, John |
| author_facet | von Morgen, Patrick Maciejowski, John |
| author_sort | von Morgen, Patrick |
| collection | PubMed |
| description | Telomere crisis is linked with many of the genomic alterations found in cancer genomes. A new understanding of how these alterations arise points towards an active role for innate immune sensors during crisis and to new opportunities for the treatment and diagnosis of cancer. |
| format | Online Article Text |
| id | pubmed-6258172 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-62581722018-11-29 The ins and outs of telomere crisis in cancer von Morgen, Patrick Maciejowski, John Genome Med Comment Telomere crisis is linked with many of the genomic alterations found in cancer genomes. A new understanding of how these alterations arise points towards an active role for innate immune sensors during crisis and to new opportunities for the treatment and diagnosis of cancer. BioMed Central 2018-11-27 /pmc/articles/PMC6258172/ /pubmed/30482235 http://dx.doi.org/10.1186/s13073-018-0596-4 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| spellingShingle | Comment von Morgen, Patrick Maciejowski, John The ins and outs of telomere crisis in cancer |
| title | The ins and outs of telomere crisis in cancer |
| title_full | The ins and outs of telomere crisis in cancer |
| title_fullStr | The ins and outs of telomere crisis in cancer |
| title_full_unstemmed | The ins and outs of telomere crisis in cancer |
| title_short | The ins and outs of telomere crisis in cancer |
| title_sort | ins and outs of telomere crisis in cancer |
| topic | Comment |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258172/ https://www.ncbi.nlm.nih.gov/pubmed/30482235 http://dx.doi.org/10.1186/s13073-018-0596-4 |
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