Data in support of toxicity studies of structurally modified plant virus to safety assessment

This data article is related to the research article entitled “Assessment of structurally modified plant virus as a novel adjuvant in toxicity studies” (Nikitin et al., 2018), devoted to the safety study of structurally modified plant virus - spherical particles (SPs). SPs are generated by thermally...

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Autores principales: Nikitin, N.A., Zenin, V.A., Trifonova, E.A., Ryabchevskaya, E.M., Yurkova, M.S., Kondakova, O.A., Fedorov, A.N., Atabekov, J.G., Karpova, O.V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Mathematics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258244/
https://www.ncbi.nlm.nih.gov/pubmed/30510980
http://dx.doi.org/10.1016/j.dib.2018.10.102
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author Nikitin, N.A.
Zenin, V.A.
Trifonova, E.A.
Ryabchevskaya, E.M.
Yurkova, M.S.
Kondakova, O.A.
Fedorov, A.N.
Atabekov, J.G.
Karpova, O.V.
author_facet Nikitin, N.A.
Zenin, V.A.
Trifonova, E.A.
Ryabchevskaya, E.M.
Yurkova, M.S.
Kondakova, O.A.
Fedorov, A.N.
Atabekov, J.G.
Karpova, O.V.
author_sort Nikitin, N.A.
collection PubMed
description This data article is related to the research article entitled “Assessment of structurally modified plant virus as a novel adjuvant in toxicity studies” (Nikitin et al., 2018), devoted to the safety study of structurally modified plant virus - spherical particles (SPs). SPs are generated by thermally denatured tobacco mosaic virus (TMV) coat protein and act as effective adjuvant for development of new vaccine candidates. This article reports the additional results on the toxicity studies of TMV SPs. The weight coefficients of laboratory animals internal organs complements the data of the subchronic toxicity studies. Also plaque-forming cell assay, delayed-type hypersensitivity test and peritoneal macrophage assay as a part of immunotoxicity studies of TMV SPs are presented.
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spelling pubmed-62582442018-12-03 Data in support of toxicity studies of structurally modified plant virus to safety assessment Nikitin, N.A. Zenin, V.A. Trifonova, E.A. Ryabchevskaya, E.M. Yurkova, M.S. Kondakova, O.A. Fedorov, A.N. Atabekov, J.G. Karpova, O.V. Data Brief Mathematics This data article is related to the research article entitled “Assessment of structurally modified plant virus as a novel adjuvant in toxicity studies” (Nikitin et al., 2018), devoted to the safety study of structurally modified plant virus - spherical particles (SPs). SPs are generated by thermally denatured tobacco mosaic virus (TMV) coat protein and act as effective adjuvant for development of new vaccine candidates. This article reports the additional results on the toxicity studies of TMV SPs. The weight coefficients of laboratory animals internal organs complements the data of the subchronic toxicity studies. Also plaque-forming cell assay, delayed-type hypersensitivity test and peritoneal macrophage assay as a part of immunotoxicity studies of TMV SPs are presented. Elsevier 2018-10-26 /pmc/articles/PMC6258244/ /pubmed/30510980 http://dx.doi.org/10.1016/j.dib.2018.10.102 Text en © 2018 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Mathematics
Nikitin, N.A.
Zenin, V.A.
Trifonova, E.A.
Ryabchevskaya, E.M.
Yurkova, M.S.
Kondakova, O.A.
Fedorov, A.N.
Atabekov, J.G.
Karpova, O.V.
Data in support of toxicity studies of structurally modified plant virus to safety assessment
title Data in support of toxicity studies of structurally modified plant virus to safety assessment
title_full Data in support of toxicity studies of structurally modified plant virus to safety assessment
title_fullStr Data in support of toxicity studies of structurally modified plant virus to safety assessment
title_full_unstemmed Data in support of toxicity studies of structurally modified plant virus to safety assessment
title_short Data in support of toxicity studies of structurally modified plant virus to safety assessment
title_sort data in support of toxicity studies of structurally modified plant virus to safety assessment
topic Mathematics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258244/
https://www.ncbi.nlm.nih.gov/pubmed/30510980
http://dx.doi.org/10.1016/j.dib.2018.10.102
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