Single-cell RNA-sequencing reveals transcriptional dynamics of estrogen-induced dysplasia in the ovarian surface epithelium

Estrogen therapy increases the risk of ovarian cancer and exogenous estradiol accelerates the onset of ovarian cancer in mouse models. Both in vivo and in vitro, ovarian surface epithelial (OSE) cells exposed to estradiol develop a subpopulation that loses cell polarity, contact inhibition, and form...

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Detalles Bibliográficos
Autores principales: Vuong, Nhung H., Cook, David P., Forrest, Laura A., Carter, Lauren E., Robineau-Charette, Pascale, Kofsky, Joshua M., Hodgkinson, Kendra M., Vanderhyden, Barbara C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258431/
https://www.ncbi.nlm.nih.gov/pubmed/30418965
http://dx.doi.org/10.1371/journal.pgen.1007788

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