HIV-1 capsids from B27/B57(+) elite controllers escape Mx2 but are targeted by TRIM5α, leading to the induction of an antiviral state

Elite controllers (ECs) are a rare subset of HIV-1 slow progressors characterized by prolonged viremia suppression. HLA alleles B27 and B57 promote the cytotoxic T lymphocyte (CTL)-mediated depletion of infected cells in ECs, leading to the emergence of escape mutations in the viral capsid (CA). Whe...

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Detalles Bibliográficos
Autores principales: Merindol, Natacha, El-Far, Mohamed, Sylla, Mohamed, Masroori, Nasser, Dufour, Caroline, Li, Jia-xin, Cherry, Pearl, Plourde, Mélodie B., Tremblay, Cécile, Berthoux, Lionel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258467/
https://www.ncbi.nlm.nih.gov/pubmed/30419009
http://dx.doi.org/10.1371/journal.ppat.1007398

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