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Clinical features of 2041 human brucellosis cases in China
BACKGROUND: Human brucellosis has become a major public health problem in China. However, the available clinical data on brucellosis cases are limited. METHODS: We retrospectively reviewed medical charts of 2041 patients with confirmed human brucellosis and prospectively recorded their outcomes by t...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258468/ https://www.ncbi.nlm.nih.gov/pubmed/30476930 http://dx.doi.org/10.1371/journal.pone.0205500 |
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author | Shi, Yujing Gao, Hui Pappas, Georgios Chen, Qiulan Li, Mei Xu, Jun Lai, Shengjie Liao, Qiaohong Yang, Wenwen Yi, Zhongtao Rouzi, Zulaguli Yu, Hongjie |
author_facet | Shi, Yujing Gao, Hui Pappas, Georgios Chen, Qiulan Li, Mei Xu, Jun Lai, Shengjie Liao, Qiaohong Yang, Wenwen Yi, Zhongtao Rouzi, Zulaguli Yu, Hongjie |
author_sort | Shi, Yujing |
collection | PubMed |
description | BACKGROUND: Human brucellosis has become a major public health problem in China. However, the available clinical data on brucellosis cases are limited. METHODS: We retrospectively reviewed medical charts of 2041 patients with confirmed human brucellosis and prospectively recorded their outcomes by telephone interview. These patients were admitted to the Sixth People’s Hospital of the Xinjiang Uygur Autonomous region between 1(st) January and 31(st) December 2014. Data on these patients were collected from hospital medical records. RESULTS: Many patients presented with fatigue (67%), fever (64%), arthralgia (63%) and sweating (54%). High erythrocyte sedimentation rate (ESR) (69%), high C-reactive protein (CRP) (39%), high alanine aminotransferase (ALT) (33%) and high aspartate aminotransferase (AST) (20%) were the most common laboratory findings, especially in acute patients. There was evidence of focal involvement in 90% of patients. A total of 61.5% of brucellosis patients recovered. Multivariate logistic regression analyses suggested that the risk factors key to unfavorable prognosis were: age≥45 years (OR = 1.75, 95% CI 1.36–2.24), back pain (OR = 1.50, 95% CI 1.16–1.94) and joint tenderness (OR = 1.73, 95% CI 1.13–2.65). The increasing duration of the illness increased the risk of poor prognosis. CONCLUSION: Patients with brucellosis showed different characteristics in different clinical stages. In China, the chronicity rate of human brucellosis is high. The risk of poor prognosis is increased in patients aged 45 years or older, patients who have had brucellosis for a substantial period of time, and patients with back pain or joint tenderness. The clinical management of brucellosis should be improved to include sensitive diagnostic methods for subacute and chronic brucellosis. |
format | Online Article Text |
id | pubmed-6258468 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-62584682018-12-06 Clinical features of 2041 human brucellosis cases in China Shi, Yujing Gao, Hui Pappas, Georgios Chen, Qiulan Li, Mei Xu, Jun Lai, Shengjie Liao, Qiaohong Yang, Wenwen Yi, Zhongtao Rouzi, Zulaguli Yu, Hongjie PLoS One Research Article BACKGROUND: Human brucellosis has become a major public health problem in China. However, the available clinical data on brucellosis cases are limited. METHODS: We retrospectively reviewed medical charts of 2041 patients with confirmed human brucellosis and prospectively recorded their outcomes by telephone interview. These patients were admitted to the Sixth People’s Hospital of the Xinjiang Uygur Autonomous region between 1(st) January and 31(st) December 2014. Data on these patients were collected from hospital medical records. RESULTS: Many patients presented with fatigue (67%), fever (64%), arthralgia (63%) and sweating (54%). High erythrocyte sedimentation rate (ESR) (69%), high C-reactive protein (CRP) (39%), high alanine aminotransferase (ALT) (33%) and high aspartate aminotransferase (AST) (20%) were the most common laboratory findings, especially in acute patients. There was evidence of focal involvement in 90% of patients. A total of 61.5% of brucellosis patients recovered. Multivariate logistic regression analyses suggested that the risk factors key to unfavorable prognosis were: age≥45 years (OR = 1.75, 95% CI 1.36–2.24), back pain (OR = 1.50, 95% CI 1.16–1.94) and joint tenderness (OR = 1.73, 95% CI 1.13–2.65). The increasing duration of the illness increased the risk of poor prognosis. CONCLUSION: Patients with brucellosis showed different characteristics in different clinical stages. In China, the chronicity rate of human brucellosis is high. The risk of poor prognosis is increased in patients aged 45 years or older, patients who have had brucellosis for a substantial period of time, and patients with back pain or joint tenderness. The clinical management of brucellosis should be improved to include sensitive diagnostic methods for subacute and chronic brucellosis. Public Library of Science 2018-11-26 /pmc/articles/PMC6258468/ /pubmed/30476930 http://dx.doi.org/10.1371/journal.pone.0205500 Text en © 2018 Shi et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Shi, Yujing Gao, Hui Pappas, Georgios Chen, Qiulan Li, Mei Xu, Jun Lai, Shengjie Liao, Qiaohong Yang, Wenwen Yi, Zhongtao Rouzi, Zulaguli Yu, Hongjie Clinical features of 2041 human brucellosis cases in China |
title | Clinical features of 2041 human brucellosis cases in China |
title_full | Clinical features of 2041 human brucellosis cases in China |
title_fullStr | Clinical features of 2041 human brucellosis cases in China |
title_full_unstemmed | Clinical features of 2041 human brucellosis cases in China |
title_short | Clinical features of 2041 human brucellosis cases in China |
title_sort | clinical features of 2041 human brucellosis cases in china |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258468/ https://www.ncbi.nlm.nih.gov/pubmed/30476930 http://dx.doi.org/10.1371/journal.pone.0205500 |
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