TRIM28 protects TRIM24 from SPOP-mediated degradation and promotes prostate cancer progression

TRIM24 is an effector substrate of the E3 ubiquitin ligase adaptor SPOP and becomes stabilized in prostate cancer (PCa) with SPOP mutations. However, how TRIM24 protein is regulated in the vast majority of SPOP-wildtype PCa is unknown. Here we report TRIM28 as a critical upstream regulator of TRIM24...

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Detalles Bibliográficos
Autores principales: Fong, Ka-wing, Zhao, Jonathan C., Song, Bing, Zheng, Bin, Yu, Jindan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258673/
https://www.ncbi.nlm.nih.gov/pubmed/30479348
http://dx.doi.org/10.1038/s41467-018-07475-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258673/
https://www.ncbi.nlm.nih.gov/pubmed/30479348
http://dx.doi.org/10.1038/s41467-018-07475-5

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