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Slx5-Slx8 ubiquitin ligase targets active pools of the Yen1 nuclease to limit crossover formation
The repair of double-stranded DNA breaks (DSBs) by homologous recombination involves the formation of branched intermediates that can lead to crossovers following nucleolytic resolution. The nucleases Mus81-Mms4 and Yen1 are tightly controlled during the cell cycle to limit the extent of crossover f...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258734/ https://www.ncbi.nlm.nih.gov/pubmed/30479332 http://dx.doi.org/10.1038/s41467-018-07364-x |