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Acute toxic encephalopathy induced by occupational exposure to 1,2-dichloropropane
1,2-Dichloropropane (1,2-DCP) is used widely in Korea as a substitute for trichloroethylene or methylene chloride. Some companies mistakenly consider that 1,2-DCP is an eco-friendly detergent because its use is not regulated, but 1,2-DCP is known to inhibit the central nervous system in animals; a f...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Institute of Occupational Safety and Health, Japan
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258745/ https://www.ncbi.nlm.nih.gov/pubmed/29973469 http://dx.doi.org/10.2486/indhealth.2018-0118 |
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author | KWAK, Kyeong Min JEONG, Kyoung Sook SHIN, Dong Hoon CHOI, Won-Jun KIM, Hyun Soo KANG, Seong-Kyu |
author_facet | KWAK, Kyeong Min JEONG, Kyoung Sook SHIN, Dong Hoon CHOI, Won-Jun KIM, Hyun Soo KANG, Seong-Kyu |
author_sort | KWAK, Kyeong Min |
collection | PubMed |
description | 1,2-Dichloropropane (1,2-DCP) is used widely in Korea as a substitute for trichloroethylene or methylene chloride. Some companies mistakenly consider that 1,2-DCP is an eco-friendly detergent because its use is not regulated, but 1,2-DCP is known to inhibit the central nervous system in animals; a few cases of accidental exposure have been reported in humans. We present a case of acute encephalopathy caused by exposure to 1,2-DCP. A 41 yr-old male presented with dizziness, headache, and diplopia after exposure to the detergent without protective equipment. Brain magnetic resonance imaging suggested metabolic encephalopathy, but the patient had no thiamine deficiency and no other metabolic disorder. As the symptoms had commenced after exposure to a large amount of solvent while skimming rust from the surface, and as the symptoms were more severe during the work week, improved on weekends, and disappeared after solvent exposure ceased, the toxic encephalopathy was likely induced by inhalation of the detergent. |
format | Online Article Text |
id | pubmed-6258745 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | National Institute of Occupational Safety and Health, Japan |
record_format | MEDLINE/PubMed |
spelling | pubmed-62587452018-12-06 Acute toxic encephalopathy induced by occupational exposure to 1,2-dichloropropane KWAK, Kyeong Min JEONG, Kyoung Sook SHIN, Dong Hoon CHOI, Won-Jun KIM, Hyun Soo KANG, Seong-Kyu Ind Health Case Report 1,2-Dichloropropane (1,2-DCP) is used widely in Korea as a substitute for trichloroethylene or methylene chloride. Some companies mistakenly consider that 1,2-DCP is an eco-friendly detergent because its use is not regulated, but 1,2-DCP is known to inhibit the central nervous system in animals; a few cases of accidental exposure have been reported in humans. We present a case of acute encephalopathy caused by exposure to 1,2-DCP. A 41 yr-old male presented with dizziness, headache, and diplopia after exposure to the detergent without protective equipment. Brain magnetic resonance imaging suggested metabolic encephalopathy, but the patient had no thiamine deficiency and no other metabolic disorder. As the symptoms had commenced after exposure to a large amount of solvent while skimming rust from the surface, and as the symptoms were more severe during the work week, improved on weekends, and disappeared after solvent exposure ceased, the toxic encephalopathy was likely induced by inhalation of the detergent. National Institute of Occupational Safety and Health, Japan 2018-07-03 2018-11 /pmc/articles/PMC6258745/ /pubmed/29973469 http://dx.doi.org/10.2486/indhealth.2018-0118 Text en ©2018 National Institute of Occupational Safety and Health This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Case Report KWAK, Kyeong Min JEONG, Kyoung Sook SHIN, Dong Hoon CHOI, Won-Jun KIM, Hyun Soo KANG, Seong-Kyu Acute toxic encephalopathy induced by occupational exposure to 1,2-dichloropropane |
title | Acute toxic encephalopathy induced by occupational exposure to
1,2-dichloropropane |
title_full | Acute toxic encephalopathy induced by occupational exposure to
1,2-dichloropropane |
title_fullStr | Acute toxic encephalopathy induced by occupational exposure to
1,2-dichloropropane |
title_full_unstemmed | Acute toxic encephalopathy induced by occupational exposure to
1,2-dichloropropane |
title_short | Acute toxic encephalopathy induced by occupational exposure to
1,2-dichloropropane |
title_sort | acute toxic encephalopathy induced by occupational exposure to
1,2-dichloropropane |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258745/ https://www.ncbi.nlm.nih.gov/pubmed/29973469 http://dx.doi.org/10.2486/indhealth.2018-0118 |
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