Macrophage-derived netrin-1 promotes abdominal aortic aneurysm formation by activating MMP3 in vascular smooth muscle cells

Abdominal aortic aneurysms (AAA) are characterized by extensive extracellular matrix (ECM) fragmentation and inflammation. However, the mechanisms by which these events are coupled thereby fueling focal vascular damage are undefined. Here we report through single-cell RNA-sequencing of diseased aort...

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Detalles Bibliográficos
Autores principales: Hadi, Tarik, Boytard, Ludovic, Silvestro, Michele, Alebrahim, Dornazsadat, Jacob, Samson, Feinstein, Jordyn, Barone, Krista, Spiro, Wes, Hutchison, Susan, Simon, Russell, Rateri, Debra, Pinet, Florence, Fenyo, David, Adelman, Mark, Moore, Kathryn J., Eltzschig, Holger K., Daugherty, Alan, Ramkhelawon, Bhama
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258757/
https://www.ncbi.nlm.nih.gov/pubmed/30479344
http://dx.doi.org/10.1038/s41467-018-07495-1

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