circGprc5a Promoted Bladder Oncogenesis and Metastasis through Gprc5a-Targeting Peptide

Bladder cancer is a serious cancer in the world, especially in advanced countries. Bladder cancer stem cells (CSCs) drive bladder tumorigenesis and metastasis. Circular RNAs (circRNAs) are involved in many biological processes, but their roles in bladder oncogenesis and bladder CSCs are unclear. Her...

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Autores principales: Gu, Chaohui, Zhou, Naichun, Wang, Zhiyu, Li, Guanru, Kou, Yipping, Yu, Shunli, Feng, Yongjie, Chen, Long, Yang, Jinjian, Tian, Fengyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258829/
https://www.ncbi.nlm.nih.gov/pubmed/30497053
http://dx.doi.org/10.1016/j.omtn.2018.10.008
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author Gu, Chaohui
Zhou, Naichun
Wang, Zhiyu
Li, Guanru
Kou, Yipping
Yu, Shunli
Feng, Yongjie
Chen, Long
Yang, Jinjian
Tian, Fengyan
author_facet Gu, Chaohui
Zhou, Naichun
Wang, Zhiyu
Li, Guanru
Kou, Yipping
Yu, Shunli
Feng, Yongjie
Chen, Long
Yang, Jinjian
Tian, Fengyan
author_sort Gu, Chaohui
collection PubMed
description Bladder cancer is a serious cancer in the world, especially in advanced countries. Bladder cancer stem cells (CSCs) drive bladder tumorigenesis and metastasis. Circular RNAs (circRNAs) are involved in many biological processes, but their roles in bladder oncogenesis and bladder CSCs are unclear. Here, we identified that circGprc5a is upregulated in bladder tumors and CSCs. circGpr5a knockdown impairs the self-renewal and metastasis of bladder CSCs, and its overexpression exerts an opposite role. circGpr5a has peptide-coding potential and functions through a peptide-dependent manner. circGprc5a-peptide binds to Gprc5a, a surface protein highly expressed in bladder CSCs. Gprc5a knockout inhibits the bladder CSC self-renewal and metastasis. circGprc5a-peptide-Gprc5a can be utilized to target bladder cancer and bladder CSCs.
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spelling pubmed-62588292018-12-19 circGprc5a Promoted Bladder Oncogenesis and Metastasis through Gprc5a-Targeting Peptide Gu, Chaohui Zhou, Naichun Wang, Zhiyu Li, Guanru Kou, Yipping Yu, Shunli Feng, Yongjie Chen, Long Yang, Jinjian Tian, Fengyan Mol Ther Nucleic Acids Article Bladder cancer is a serious cancer in the world, especially in advanced countries. Bladder cancer stem cells (CSCs) drive bladder tumorigenesis and metastasis. Circular RNAs (circRNAs) are involved in many biological processes, but their roles in bladder oncogenesis and bladder CSCs are unclear. Here, we identified that circGprc5a is upregulated in bladder tumors and CSCs. circGpr5a knockdown impairs the self-renewal and metastasis of bladder CSCs, and its overexpression exerts an opposite role. circGpr5a has peptide-coding potential and functions through a peptide-dependent manner. circGprc5a-peptide binds to Gprc5a, a surface protein highly expressed in bladder CSCs. Gprc5a knockout inhibits the bladder CSC self-renewal and metastasis. circGprc5a-peptide-Gprc5a can be utilized to target bladder cancer and bladder CSCs. American Society of Gene & Cell Therapy 2018-10-18 /pmc/articles/PMC6258829/ /pubmed/30497053 http://dx.doi.org/10.1016/j.omtn.2018.10.008 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Gu, Chaohui
Zhou, Naichun
Wang, Zhiyu
Li, Guanru
Kou, Yipping
Yu, Shunli
Feng, Yongjie
Chen, Long
Yang, Jinjian
Tian, Fengyan
circGprc5a Promoted Bladder Oncogenesis and Metastasis through Gprc5a-Targeting Peptide
title circGprc5a Promoted Bladder Oncogenesis and Metastasis through Gprc5a-Targeting Peptide
title_full circGprc5a Promoted Bladder Oncogenesis and Metastasis through Gprc5a-Targeting Peptide
title_fullStr circGprc5a Promoted Bladder Oncogenesis and Metastasis through Gprc5a-Targeting Peptide
title_full_unstemmed circGprc5a Promoted Bladder Oncogenesis and Metastasis through Gprc5a-Targeting Peptide
title_short circGprc5a Promoted Bladder Oncogenesis and Metastasis through Gprc5a-Targeting Peptide
title_sort circgprc5a promoted bladder oncogenesis and metastasis through gprc5a-targeting peptide
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258829/
https://www.ncbi.nlm.nih.gov/pubmed/30497053
http://dx.doi.org/10.1016/j.omtn.2018.10.008
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