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Efficient Induction of T Cells against Conserved HIV-1 Regions by Mosaic Vaccines Delivered as Self-Amplifying mRNA

Focusing T cell responses on the most vulnerable parts of HIV-1, the functionally conserved regions of HIV-1 proteins, is likely a key prerequisite for vaccine success. For a T cell vaccine to efficiently control HIV-1 replication, the vaccine-elicited individual CD8(+) T cells and as a population h...

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Detalles Bibliográficos
Autores principales:	Moyo, Nathifa, Vogel, Annette B., Buus, Søren, Erbar, Stephanie, Wee, Edmund G., Sahin, Ugur, Hanke, Tomáš
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258890/ https://www.ncbi.nlm.nih.gov/pubmed/30547051 http://dx.doi.org/10.1016/j.omtm.2018.10.010

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