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Common features of atopic dermatitis with hypoproteinemia

PURPOSE: The purpose of this study was to identify the causes, symptoms, and complications of hypoproteinemia to prevent hypoproteinemia and provide appropriate treatment to children with atopic dermatitis. METHODS: Children diagnosed with atopic dermatitis with hypoproteinemia and/or hypoalbuminemi...

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Autores principales: Jo, So Yoon, Lee, Chan-Ho, Jung, Woo-Jin, Kim, Sung-Won, Hwang, Yoon-Ha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Pediatric Society 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258965/
https://www.ncbi.nlm.nih.gov/pubmed/30304908
http://dx.doi.org/10.3345/kjp.2018.06324
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author Jo, So Yoon
Lee, Chan-Ho
Jung, Woo-Jin
Kim, Sung-Won
Hwang, Yoon-Ha
author_facet Jo, So Yoon
Lee, Chan-Ho
Jung, Woo-Jin
Kim, Sung-Won
Hwang, Yoon-Ha
author_sort Jo, So Yoon
collection PubMed
description PURPOSE: The purpose of this study was to identify the causes, symptoms, and complications of hypoproteinemia to prevent hypoproteinemia and provide appropriate treatment to children with atopic dermatitis. METHODS: Children diagnosed with atopic dermatitis with hypoproteinemia and/or hypoalbuminemia were retrospectively reviewed. The patients’ medical records, including family history, weight, symptoms, treatment, complications, and laboratory test results for allergies and skin cultures, were examined. RESULTS: Twenty-six patients (24 boys) were enrolled. Seven cases had growth retardation; 7, keratoconjunctivitis; 6, aural discharges; 5, eczema herpeticum; 4, gastrointestinal tract symptoms; and 2, developmental delays. In 21 cases, topical steroids were not used. According to the blood test results, the median values of each parameter were elevated: total IgE, 1,864 U/mL; egg white-specific IgE, 76.5 kU(A)/L; milk IgE, 20.5 kU(A)/L; peanut IgE, 30 kU(A)/L; eosinophil count, 5,810/μL; eosinophil cationic protein, 93.45 μg/L; and platelet count, 666.5×10(3)/μL. Serum albumin and total protein levels decreased to 2.7 g/dL and 4.25 g/dL, respectively. Regarding electrolyte abnormality, 10 patients had hyponatremia, and 12, hyperkalemia. Systemic antibiotics were used to treat all cases, and an antiviral agent was used in 12 patients. Electrolyte correction was performed in 8 patients. CONCLUSION: Hypoproteinemia accompanying atopic dermatitis is common in infants younger than 1 year and may occur because of topical steroid treatment continuously being declined or because of eczema herpeticum. It may be accompanied by growth retardation, keratoconjunctivitis, aural discharge, and eczema herpeticum and can be managed through skin care and topical steroid application without intravenous albumin infusion.
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spelling pubmed-62589652018-11-30 Common features of atopic dermatitis with hypoproteinemia Jo, So Yoon Lee, Chan-Ho Jung, Woo-Jin Kim, Sung-Won Hwang, Yoon-Ha Korean J Pediatr Original Article PURPOSE: The purpose of this study was to identify the causes, symptoms, and complications of hypoproteinemia to prevent hypoproteinemia and provide appropriate treatment to children with atopic dermatitis. METHODS: Children diagnosed with atopic dermatitis with hypoproteinemia and/or hypoalbuminemia were retrospectively reviewed. The patients’ medical records, including family history, weight, symptoms, treatment, complications, and laboratory test results for allergies and skin cultures, were examined. RESULTS: Twenty-six patients (24 boys) were enrolled. Seven cases had growth retardation; 7, keratoconjunctivitis; 6, aural discharges; 5, eczema herpeticum; 4, gastrointestinal tract symptoms; and 2, developmental delays. In 21 cases, topical steroids were not used. According to the blood test results, the median values of each parameter were elevated: total IgE, 1,864 U/mL; egg white-specific IgE, 76.5 kU(A)/L; milk IgE, 20.5 kU(A)/L; peanut IgE, 30 kU(A)/L; eosinophil count, 5,810/μL; eosinophil cationic protein, 93.45 μg/L; and platelet count, 666.5×10(3)/μL. Serum albumin and total protein levels decreased to 2.7 g/dL and 4.25 g/dL, respectively. Regarding electrolyte abnormality, 10 patients had hyponatremia, and 12, hyperkalemia. Systemic antibiotics were used to treat all cases, and an antiviral agent was used in 12 patients. Electrolyte correction was performed in 8 patients. CONCLUSION: Hypoproteinemia accompanying atopic dermatitis is common in infants younger than 1 year and may occur because of topical steroid treatment continuously being declined or because of eczema herpeticum. It may be accompanied by growth retardation, keratoconjunctivitis, aural discharge, and eczema herpeticum and can be managed through skin care and topical steroid application without intravenous albumin infusion. Korean Pediatric Society 2018-11 2018-09-16 /pmc/articles/PMC6258965/ /pubmed/30304908 http://dx.doi.org/10.3345/kjp.2018.06324 Text en Copyright © 2018 by The Korean Pediatric Society This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Jo, So Yoon
Lee, Chan-Ho
Jung, Woo-Jin
Kim, Sung-Won
Hwang, Yoon-Ha
Common features of atopic dermatitis with hypoproteinemia
title Common features of atopic dermatitis with hypoproteinemia
title_full Common features of atopic dermatitis with hypoproteinemia
title_fullStr Common features of atopic dermatitis with hypoproteinemia
title_full_unstemmed Common features of atopic dermatitis with hypoproteinemia
title_short Common features of atopic dermatitis with hypoproteinemia
title_sort common features of atopic dermatitis with hypoproteinemia
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258965/
https://www.ncbi.nlm.nih.gov/pubmed/30304908
http://dx.doi.org/10.3345/kjp.2018.06324
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