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Combined anatomical optical coherence tomography and intraluminal pressure reveal viscoelasticity of the in vivo airway

It is hypothesized that the local, viscoelastic (time-dependent) properties of the airway are important to accurately model and ultimately predict dynamic airway collapse in airway obstruction. Toward this end, we present a portable, endoscopic, swept-source anatomical optical coherence tomography (...

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Autores principales: Balakrishnan, Santosh, Bu, Ruofei, Iftimia, Nicusor, Price, Hillel, Zdanski, Carlton, Oldenburg, Amy L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society of Photo-Optical Instrumentation Engineers 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259006/
https://www.ncbi.nlm.nih.gov/pubmed/30350490
http://dx.doi.org/10.1117/1.JBO.23.10.100501
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author Balakrishnan, Santosh
Bu, Ruofei
Iftimia, Nicusor
Price, Hillel
Zdanski, Carlton
Oldenburg, Amy L.
author_facet Balakrishnan, Santosh
Bu, Ruofei
Iftimia, Nicusor
Price, Hillel
Zdanski, Carlton
Oldenburg, Amy L.
author_sort Balakrishnan, Santosh
collection PubMed
description It is hypothesized that the local, viscoelastic (time-dependent) properties of the airway are important to accurately model and ultimately predict dynamic airway collapse in airway obstruction. Toward this end, we present a portable, endoscopic, swept-source anatomical optical coherence tomography (aOCT) system combined with a pressure catheter to capture local airway dynamics in vivo during respiration. aOCT scans were performed in the airways of a mechanically ventilated pig under paralysis with dynamic and static ventilation protocols. Validation of dynamic aOCT luminal cross-sectional area (CSA) measurements against Cine CT, obtained during the same exam, showed an aggregate difference of [Formula: see text]. aOCT-derived CSA obtained in the in vivo trachea also exhibited hysteresis as a function of pressure, depicting the viscoelastic nature of the airway wall. The volumetric imaging capabilities were validated by comparing aOCT- and CT-derived geometries of the porcine airway spanning nine generations from the trachea to the bronchioles. The ability to delineate regional differences in airway viscoelastic properties, by measuring airway deformation using aOCT combined with intraluminal pressure, paves the way to patient-specific models of dynamic airway collapse.
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spelling pubmed-62590062019-10-22 Combined anatomical optical coherence tomography and intraluminal pressure reveal viscoelasticity of the in vivo airway Balakrishnan, Santosh Bu, Ruofei Iftimia, Nicusor Price, Hillel Zdanski, Carlton Oldenburg, Amy L. J Biomed Opt JBO Letters It is hypothesized that the local, viscoelastic (time-dependent) properties of the airway are important to accurately model and ultimately predict dynamic airway collapse in airway obstruction. Toward this end, we present a portable, endoscopic, swept-source anatomical optical coherence tomography (aOCT) system combined with a pressure catheter to capture local airway dynamics in vivo during respiration. aOCT scans were performed in the airways of a mechanically ventilated pig under paralysis with dynamic and static ventilation protocols. Validation of dynamic aOCT luminal cross-sectional area (CSA) measurements against Cine CT, obtained during the same exam, showed an aggregate difference of [Formula: see text]. aOCT-derived CSA obtained in the in vivo trachea also exhibited hysteresis as a function of pressure, depicting the viscoelastic nature of the airway wall. The volumetric imaging capabilities were validated by comparing aOCT- and CT-derived geometries of the porcine airway spanning nine generations from the trachea to the bronchioles. The ability to delineate regional differences in airway viscoelastic properties, by measuring airway deformation using aOCT combined with intraluminal pressure, paves the way to patient-specific models of dynamic airway collapse. Society of Photo-Optical Instrumentation Engineers 2018-10-22 2018-10 /pmc/articles/PMC6259006/ /pubmed/30350490 http://dx.doi.org/10.1117/1.JBO.23.10.100501 Text en © The Authors. https://creativecommons.org/licenses/by/3.0/ Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
spellingShingle JBO Letters
Balakrishnan, Santosh
Bu, Ruofei
Iftimia, Nicusor
Price, Hillel
Zdanski, Carlton
Oldenburg, Amy L.
Combined anatomical optical coherence tomography and intraluminal pressure reveal viscoelasticity of the in vivo airway
title Combined anatomical optical coherence tomography and intraluminal pressure reveal viscoelasticity of the in vivo airway
title_full Combined anatomical optical coherence tomography and intraluminal pressure reveal viscoelasticity of the in vivo airway
title_fullStr Combined anatomical optical coherence tomography and intraluminal pressure reveal viscoelasticity of the in vivo airway
title_full_unstemmed Combined anatomical optical coherence tomography and intraluminal pressure reveal viscoelasticity of the in vivo airway
title_short Combined anatomical optical coherence tomography and intraluminal pressure reveal viscoelasticity of the in vivo airway
title_sort combined anatomical optical coherence tomography and intraluminal pressure reveal viscoelasticity of the in vivo airway
topic JBO Letters
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259006/
https://www.ncbi.nlm.nih.gov/pubmed/30350490
http://dx.doi.org/10.1117/1.JBO.23.10.100501
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