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Antimicrobial Activity of Diterpenes from Viguiera arenaria against Endodontic Bacteria

Six pimarane-type diterpenes isolated from Viguiera arenaria Baker and two semi-synthetic derivatives were evaluated in vitro against a panel of representative microorganisms responsible for dental root canal infections. The microdilution method was used for the determination of the minimum inhibito...

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Autores principales: Carvalho, Tatiane C., Simão, Marília R., Ambrósio, Sérgio R., Furtado, Niege A. J. C., Veneziani, Rodrigo C. S., Heleno, Vladimir C. G., Da Costa, Fernando B., Gomes, Brenda P. F. A., Souza, Maria Gorete M., Borges dos Reis, Erika, Martins, Carlos H. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259102/
https://www.ncbi.nlm.nih.gov/pubmed/21233793
http://dx.doi.org/10.3390/molecules160100543
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author Carvalho, Tatiane C.
Simão, Marília R.
Ambrósio, Sérgio R.
Furtado, Niege A. J. C.
Veneziani, Rodrigo C. S.
Heleno, Vladimir C. G.
Da Costa, Fernando B.
Gomes, Brenda P. F. A.
Souza, Maria Gorete M.
Borges dos Reis, Erika
Martins, Carlos H. G.
author_facet Carvalho, Tatiane C.
Simão, Marília R.
Ambrósio, Sérgio R.
Furtado, Niege A. J. C.
Veneziani, Rodrigo C. S.
Heleno, Vladimir C. G.
Da Costa, Fernando B.
Gomes, Brenda P. F. A.
Souza, Maria Gorete M.
Borges dos Reis, Erika
Martins, Carlos H. G.
author_sort Carvalho, Tatiane C.
collection PubMed
description Six pimarane-type diterpenes isolated from Viguiera arenaria Baker and two semi-synthetic derivatives were evaluated in vitro against a panel of representative microorganisms responsible for dental root canal infections. The microdilution method was used for the determination of the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) against Porphyromonas gingivalis, Prevotella nigrescens, Prevotella intermedia, Prevotella buccae, Fusobacterium nucleatum, Bacteroides fragilis, Actinomyces naeslundii, Actinomyces viscosus, Peptostreptococcus micros, Enterococcus faecalis and Aggregatibacter actinomycetemcomitans. The compounds ent-pimara-8(14),15-dien-19-oic acid, its sodium salt and ent-8(14),15-pimaradien-3β-ol were the most active, displaying MIC values ranging from 1 to 10 μg mL(-1). The results also allow us to conclude that minor structural differences among these diterpenes significantly influence their antimicrobial activity, bringing new perspectives to the discovery of new chemicals for use as a complement to instrumental endodontic procedures.
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spelling pubmed-62591022018-12-07 Antimicrobial Activity of Diterpenes from Viguiera arenaria against Endodontic Bacteria Carvalho, Tatiane C. Simão, Marília R. Ambrósio, Sérgio R. Furtado, Niege A. J. C. Veneziani, Rodrigo C. S. Heleno, Vladimir C. G. Da Costa, Fernando B. Gomes, Brenda P. F. A. Souza, Maria Gorete M. Borges dos Reis, Erika Martins, Carlos H. G. Molecules Article Six pimarane-type diterpenes isolated from Viguiera arenaria Baker and two semi-synthetic derivatives were evaluated in vitro against a panel of representative microorganisms responsible for dental root canal infections. The microdilution method was used for the determination of the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) against Porphyromonas gingivalis, Prevotella nigrescens, Prevotella intermedia, Prevotella buccae, Fusobacterium nucleatum, Bacteroides fragilis, Actinomyces naeslundii, Actinomyces viscosus, Peptostreptococcus micros, Enterococcus faecalis and Aggregatibacter actinomycetemcomitans. The compounds ent-pimara-8(14),15-dien-19-oic acid, its sodium salt and ent-8(14),15-pimaradien-3β-ol were the most active, displaying MIC values ranging from 1 to 10 μg mL(-1). The results also allow us to conclude that minor structural differences among these diterpenes significantly influence their antimicrobial activity, bringing new perspectives to the discovery of new chemicals for use as a complement to instrumental endodontic procedures. MDPI 2011-01-13 /pmc/articles/PMC6259102/ /pubmed/21233793 http://dx.doi.org/10.3390/molecules160100543 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Carvalho, Tatiane C.
Simão, Marília R.
Ambrósio, Sérgio R.
Furtado, Niege A. J. C.
Veneziani, Rodrigo C. S.
Heleno, Vladimir C. G.
Da Costa, Fernando B.
Gomes, Brenda P. F. A.
Souza, Maria Gorete M.
Borges dos Reis, Erika
Martins, Carlos H. G.
Antimicrobial Activity of Diterpenes from Viguiera arenaria against Endodontic Bacteria
title Antimicrobial Activity of Diterpenes from Viguiera arenaria against Endodontic Bacteria
title_full Antimicrobial Activity of Diterpenes from Viguiera arenaria against Endodontic Bacteria
title_fullStr Antimicrobial Activity of Diterpenes from Viguiera arenaria against Endodontic Bacteria
title_full_unstemmed Antimicrobial Activity of Diterpenes from Viguiera arenaria against Endodontic Bacteria
title_short Antimicrobial Activity of Diterpenes from Viguiera arenaria against Endodontic Bacteria
title_sort antimicrobial activity of diterpenes from viguiera arenaria against endodontic bacteria
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259102/
https://www.ncbi.nlm.nih.gov/pubmed/21233793
http://dx.doi.org/10.3390/molecules160100543
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