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Antimicrobial Activity of Diterpenes from Viguiera arenaria against Endodontic Bacteria
Six pimarane-type diterpenes isolated from Viguiera arenaria Baker and two semi-synthetic derivatives were evaluated in vitro against a panel of representative microorganisms responsible for dental root canal infections. The microdilution method was used for the determination of the minimum inhibito...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259102/ https://www.ncbi.nlm.nih.gov/pubmed/21233793 http://dx.doi.org/10.3390/molecules160100543 |
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author | Carvalho, Tatiane C. Simão, Marília R. Ambrósio, Sérgio R. Furtado, Niege A. J. C. Veneziani, Rodrigo C. S. Heleno, Vladimir C. G. Da Costa, Fernando B. Gomes, Brenda P. F. A. Souza, Maria Gorete M. Borges dos Reis, Erika Martins, Carlos H. G. |
author_facet | Carvalho, Tatiane C. Simão, Marília R. Ambrósio, Sérgio R. Furtado, Niege A. J. C. Veneziani, Rodrigo C. S. Heleno, Vladimir C. G. Da Costa, Fernando B. Gomes, Brenda P. F. A. Souza, Maria Gorete M. Borges dos Reis, Erika Martins, Carlos H. G. |
author_sort | Carvalho, Tatiane C. |
collection | PubMed |
description | Six pimarane-type diterpenes isolated from Viguiera arenaria Baker and two semi-synthetic derivatives were evaluated in vitro against a panel of representative microorganisms responsible for dental root canal infections. The microdilution method was used for the determination of the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) against Porphyromonas gingivalis, Prevotella nigrescens, Prevotella intermedia, Prevotella buccae, Fusobacterium nucleatum, Bacteroides fragilis, Actinomyces naeslundii, Actinomyces viscosus, Peptostreptococcus micros, Enterococcus faecalis and Aggregatibacter actinomycetemcomitans. The compounds ent-pimara-8(14),15-dien-19-oic acid, its sodium salt and ent-8(14),15-pimaradien-3β-ol were the most active, displaying MIC values ranging from 1 to 10 μg mL(-1). The results also allow us to conclude that minor structural differences among these diterpenes significantly influence their antimicrobial activity, bringing new perspectives to the discovery of new chemicals for use as a complement to instrumental endodontic procedures. |
format | Online Article Text |
id | pubmed-6259102 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62591022018-12-07 Antimicrobial Activity of Diterpenes from Viguiera arenaria against Endodontic Bacteria Carvalho, Tatiane C. Simão, Marília R. Ambrósio, Sérgio R. Furtado, Niege A. J. C. Veneziani, Rodrigo C. S. Heleno, Vladimir C. G. Da Costa, Fernando B. Gomes, Brenda P. F. A. Souza, Maria Gorete M. Borges dos Reis, Erika Martins, Carlos H. G. Molecules Article Six pimarane-type diterpenes isolated from Viguiera arenaria Baker and two semi-synthetic derivatives were evaluated in vitro against a panel of representative microorganisms responsible for dental root canal infections. The microdilution method was used for the determination of the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) against Porphyromonas gingivalis, Prevotella nigrescens, Prevotella intermedia, Prevotella buccae, Fusobacterium nucleatum, Bacteroides fragilis, Actinomyces naeslundii, Actinomyces viscosus, Peptostreptococcus micros, Enterococcus faecalis and Aggregatibacter actinomycetemcomitans. The compounds ent-pimara-8(14),15-dien-19-oic acid, its sodium salt and ent-8(14),15-pimaradien-3β-ol were the most active, displaying MIC values ranging from 1 to 10 μg mL(-1). The results also allow us to conclude that minor structural differences among these diterpenes significantly influence their antimicrobial activity, bringing new perspectives to the discovery of new chemicals for use as a complement to instrumental endodontic procedures. MDPI 2011-01-13 /pmc/articles/PMC6259102/ /pubmed/21233793 http://dx.doi.org/10.3390/molecules160100543 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Carvalho, Tatiane C. Simão, Marília R. Ambrósio, Sérgio R. Furtado, Niege A. J. C. Veneziani, Rodrigo C. S. Heleno, Vladimir C. G. Da Costa, Fernando B. Gomes, Brenda P. F. A. Souza, Maria Gorete M. Borges dos Reis, Erika Martins, Carlos H. G. Antimicrobial Activity of Diterpenes from Viguiera arenaria against Endodontic Bacteria |
title | Antimicrobial Activity of Diterpenes from Viguiera arenaria against Endodontic Bacteria |
title_full | Antimicrobial Activity of Diterpenes from Viguiera arenaria against Endodontic Bacteria |
title_fullStr | Antimicrobial Activity of Diterpenes from Viguiera arenaria against Endodontic Bacteria |
title_full_unstemmed | Antimicrobial Activity of Diterpenes from Viguiera arenaria against Endodontic Bacteria |
title_short | Antimicrobial Activity of Diterpenes from Viguiera arenaria against Endodontic Bacteria |
title_sort | antimicrobial activity of diterpenes from viguiera arenaria against endodontic bacteria |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259102/ https://www.ncbi.nlm.nih.gov/pubmed/21233793 http://dx.doi.org/10.3390/molecules160100543 |
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