Synthesis of 6-Amino-5-cyano-1,4-disubstituted-2(1H)-Pyrimidinones via Copper-(I)-catalyzed Alkyne-azide ‘Click Chemistry’ and Their Reactivity

In this paper we present the room temperature synthesis of a novel serie of 1,4-disubstituted-1,2,3-triazoles 4a-l by employing the (3 + 2) cycloaddition reaction of pyrimidinones containing alkyne functions with different model azides in the presence of copper sulphate and sodium ascorbate. To obta...

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Detalles Bibliográficos
Autores principales: Najahi, Ennaji, Sudor, Jan, Chabchoub, Fakher, Nepveu, Françoise, Zribi, Fethi, Duval, Romain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259112/
https://www.ncbi.nlm.nih.gov/pubmed/21131903
http://dx.doi.org/10.3390/molecules15128841

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259112/
https://www.ncbi.nlm.nih.gov/pubmed/21131903
http://dx.doi.org/10.3390/molecules15128841

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