A Route to Dicyanomethylene Pyridines and Substituted Benzonitriles Utilizing Malononitrile Dimer as a Precursor

The conditions of the reaction of malononitrile dimer with enaminones and arylidenemalononitrile could be adapted to yield either pyridines or benzene derivatives. A new synthesis of pyrido[1,2-a]pyrimidines from the reaction of malononitrile dimer 1 and 2-phenyl-3-piperidin-1-yl-acrylonitrile (11)...

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Autores principales: Helmy, Noha M., El-Baih, Fatma E. M., Al-Alshaikh, Monirah A., Moustafa, Moustafa S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259116/
https://www.ncbi.nlm.nih.gov/pubmed/21266943
http://dx.doi.org/10.3390/molecules16010298
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author Helmy, Noha M.
El-Baih, Fatma E. M.
Al-Alshaikh, Monirah A.
Moustafa, Moustafa S.
author_facet Helmy, Noha M.
El-Baih, Fatma E. M.
Al-Alshaikh, Monirah A.
Moustafa, Moustafa S.
author_sort Helmy, Noha M.
collection PubMed
description The conditions of the reaction of malononitrile dimer with enaminones and arylidenemalononitrile could be adapted to yield either pyridines or benzene derivatives. A new synthesis of pyrido[1,2-a]pyrimidines from the reaction of malononitrile dimer 1 and 2-phenyl-3-piperidin-1-yl-acrylonitrile (11) is described. Compound 1 condensed with DMFDMA to yield an enaminonitrile that reacted with hydrazine hydrate to yield N',4,6-triamino-2H-pyrazolo[3,4-b]pyridine-5-carboxamidine (17).
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spelling pubmed-62591162018-12-07 A Route to Dicyanomethylene Pyridines and Substituted Benzonitriles Utilizing Malononitrile Dimer as a Precursor Helmy, Noha M. El-Baih, Fatma E. M. Al-Alshaikh, Monirah A. Moustafa, Moustafa S. Molecules Article The conditions of the reaction of malononitrile dimer with enaminones and arylidenemalononitrile could be adapted to yield either pyridines or benzene derivatives. A new synthesis of pyrido[1,2-a]pyrimidines from the reaction of malononitrile dimer 1 and 2-phenyl-3-piperidin-1-yl-acrylonitrile (11) is described. Compound 1 condensed with DMFDMA to yield an enaminonitrile that reacted with hydrazine hydrate to yield N',4,6-triamino-2H-pyrazolo[3,4-b]pyridine-5-carboxamidine (17). MDPI 2011-01-04 /pmc/articles/PMC6259116/ /pubmed/21266943 http://dx.doi.org/10.3390/molecules16010298 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Helmy, Noha M.
El-Baih, Fatma E. M.
Al-Alshaikh, Monirah A.
Moustafa, Moustafa S.
A Route to Dicyanomethylene Pyridines and Substituted Benzonitriles Utilizing Malononitrile Dimer as a Precursor
title A Route to Dicyanomethylene Pyridines and Substituted Benzonitriles Utilizing Malononitrile Dimer as a Precursor
title_full A Route to Dicyanomethylene Pyridines and Substituted Benzonitriles Utilizing Malononitrile Dimer as a Precursor
title_fullStr A Route to Dicyanomethylene Pyridines and Substituted Benzonitriles Utilizing Malononitrile Dimer as a Precursor
title_full_unstemmed A Route to Dicyanomethylene Pyridines and Substituted Benzonitriles Utilizing Malononitrile Dimer as a Precursor
title_short A Route to Dicyanomethylene Pyridines and Substituted Benzonitriles Utilizing Malononitrile Dimer as a Precursor
title_sort route to dicyanomethylene pyridines and substituted benzonitriles utilizing malononitrile dimer as a precursor
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259116/
https://www.ncbi.nlm.nih.gov/pubmed/21266943
http://dx.doi.org/10.3390/molecules16010298
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