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The Discovery of Small-Molecule Mimicking Peptides through Phage Display

Using peptides to achieve the functional and structural mimicry of small-molecules, especially those with biological activity or clear biotechnological applications, has great potential in overcoming difficulties associated with synthesis, or unfavorable physical properties. Combinatorial techniques...

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Detalles Bibliográficos
Autores principales: Dudak, Fahriye Ceyda, Boyaci, Ismail Hakki, Orner, Brendan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259150/
https://www.ncbi.nlm.nih.gov/pubmed/21248663
http://dx.doi.org/10.3390/molecules16010774
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author Dudak, Fahriye Ceyda
Boyaci, Ismail Hakki
Orner, Brendan P.
author_facet Dudak, Fahriye Ceyda
Boyaci, Ismail Hakki
Orner, Brendan P.
author_sort Dudak, Fahriye Ceyda
collection PubMed
description Using peptides to achieve the functional and structural mimicry of small-molecules, especially those with biological activity or clear biotechnological applications, has great potential in overcoming difficulties associated with synthesis, or unfavorable physical properties. Combinatorial techniques like phage display can aid in the discovery of these peptides even if their mechanism of mimicry is not rationally obvious.The major focus of this field has been limited to developing biotin and sugar mimetics. However, the full “mimicry” of these peptides has not yet been fully established as some bind to the target with a different mechanism than that of the natural ligand and some do not share all of the natural ligand’s binding partners. In this article, mimicry of small-molecules by phage display-discovered peptides is reviewed and their potential in biochemical and medical applications is analyzed.
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spelling pubmed-62591502018-12-07 The Discovery of Small-Molecule Mimicking Peptides through Phage Display Dudak, Fahriye Ceyda Boyaci, Ismail Hakki Orner, Brendan P. Molecules Review Using peptides to achieve the functional and structural mimicry of small-molecules, especially those with biological activity or clear biotechnological applications, has great potential in overcoming difficulties associated with synthesis, or unfavorable physical properties. Combinatorial techniques like phage display can aid in the discovery of these peptides even if their mechanism of mimicry is not rationally obvious.The major focus of this field has been limited to developing biotin and sugar mimetics. However, the full “mimicry” of these peptides has not yet been fully established as some bind to the target with a different mechanism than that of the natural ligand and some do not share all of the natural ligand’s binding partners. In this article, mimicry of small-molecules by phage display-discovered peptides is reviewed and their potential in biochemical and medical applications is analyzed. MDPI 2011-01-19 /pmc/articles/PMC6259150/ /pubmed/21248663 http://dx.doi.org/10.3390/molecules16010774 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Dudak, Fahriye Ceyda
Boyaci, Ismail Hakki
Orner, Brendan P.
The Discovery of Small-Molecule Mimicking Peptides through Phage Display
title The Discovery of Small-Molecule Mimicking Peptides through Phage Display
title_full The Discovery of Small-Molecule Mimicking Peptides through Phage Display
title_fullStr The Discovery of Small-Molecule Mimicking Peptides through Phage Display
title_full_unstemmed The Discovery of Small-Molecule Mimicking Peptides through Phage Display
title_short The Discovery of Small-Molecule Mimicking Peptides through Phage Display
title_sort discovery of small-molecule mimicking peptides through phage display
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259150/
https://www.ncbi.nlm.nih.gov/pubmed/21248663
http://dx.doi.org/10.3390/molecules16010774
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