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The Discovery of Small-Molecule Mimicking Peptides through Phage Display
Using peptides to achieve the functional and structural mimicry of small-molecules, especially those with biological activity or clear biotechnological applications, has great potential in overcoming difficulties associated with synthesis, or unfavorable physical properties. Combinatorial techniques...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259150/ https://www.ncbi.nlm.nih.gov/pubmed/21248663 http://dx.doi.org/10.3390/molecules16010774 |
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author | Dudak, Fahriye Ceyda Boyaci, Ismail Hakki Orner, Brendan P. |
author_facet | Dudak, Fahriye Ceyda Boyaci, Ismail Hakki Orner, Brendan P. |
author_sort | Dudak, Fahriye Ceyda |
collection | PubMed |
description | Using peptides to achieve the functional and structural mimicry of small-molecules, especially those with biological activity or clear biotechnological applications, has great potential in overcoming difficulties associated with synthesis, or unfavorable physical properties. Combinatorial techniques like phage display can aid in the discovery of these peptides even if their mechanism of mimicry is not rationally obvious.The major focus of this field has been limited to developing biotin and sugar mimetics. However, the full “mimicry” of these peptides has not yet been fully established as some bind to the target with a different mechanism than that of the natural ligand and some do not share all of the natural ligand’s binding partners. In this article, mimicry of small-molecules by phage display-discovered peptides is reviewed and their potential in biochemical and medical applications is analyzed. |
format | Online Article Text |
id | pubmed-6259150 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62591502018-12-07 The Discovery of Small-Molecule Mimicking Peptides through Phage Display Dudak, Fahriye Ceyda Boyaci, Ismail Hakki Orner, Brendan P. Molecules Review Using peptides to achieve the functional and structural mimicry of small-molecules, especially those with biological activity or clear biotechnological applications, has great potential in overcoming difficulties associated with synthesis, or unfavorable physical properties. Combinatorial techniques like phage display can aid in the discovery of these peptides even if their mechanism of mimicry is not rationally obvious.The major focus of this field has been limited to developing biotin and sugar mimetics. However, the full “mimicry” of these peptides has not yet been fully established as some bind to the target with a different mechanism than that of the natural ligand and some do not share all of the natural ligand’s binding partners. In this article, mimicry of small-molecules by phage display-discovered peptides is reviewed and their potential in biochemical and medical applications is analyzed. MDPI 2011-01-19 /pmc/articles/PMC6259150/ /pubmed/21248663 http://dx.doi.org/10.3390/molecules16010774 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Dudak, Fahriye Ceyda Boyaci, Ismail Hakki Orner, Brendan P. The Discovery of Small-Molecule Mimicking Peptides through Phage Display |
title | The Discovery of Small-Molecule Mimicking Peptides through Phage Display |
title_full | The Discovery of Small-Molecule Mimicking Peptides through Phage Display |
title_fullStr | The Discovery of Small-Molecule Mimicking Peptides through Phage Display |
title_full_unstemmed | The Discovery of Small-Molecule Mimicking Peptides through Phage Display |
title_short | The Discovery of Small-Molecule Mimicking Peptides through Phage Display |
title_sort | discovery of small-molecule mimicking peptides through phage display |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259150/ https://www.ncbi.nlm.nih.gov/pubmed/21248663 http://dx.doi.org/10.3390/molecules16010774 |
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