Evaluation of the Bioactivity of Novel Spiroisoxazoline Type Compounds against Normal and Cancer Cell Lines

The aim of this study was to investigate the in vitro cellular activity of novel spiroisoxazoline type compounds against normal and cancer cell lines from lung tissue (Hs888Lu), neuron-phenotypic cells (SH-SY5Y), neuroblastoma (SH-SY5Y), human histiocytic lymphoma (U937), lung cancer (A549), and leu...

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Autores principales: Najim, Nigar, Bathich, Yaser, Zain, Mazatulikhma Mat, Hamzah, Ahmad Sazali, Shaameri, Zurina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259157/
https://www.ncbi.nlm.nih.gov/pubmed/21169884
http://dx.doi.org/10.3390/molecules15129340
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author Najim, Nigar
Bathich, Yaser
Zain, Mazatulikhma Mat
Hamzah, Ahmad Sazali
Shaameri, Zurina
author_facet Najim, Nigar
Bathich, Yaser
Zain, Mazatulikhma Mat
Hamzah, Ahmad Sazali
Shaameri, Zurina
author_sort Najim, Nigar
collection PubMed
description The aim of this study was to investigate the in vitro cellular activity of novel spiroisoxazoline type compounds against normal and cancer cell lines from lung tissue (Hs888Lu), neuron-phenotypic cells (SH-SY5Y), neuroblastoma (SH-SY5Y), human histiocytic lymphoma (U937), lung cancer (A549), and leukaemia (HL-60). Our bioassay program revealed that the spiroisoxazoline type compounds show cytotoxicity only in lymphoma cell lines, which is in contrast with the pyrrolidine precursor of these spiroisoxazoline compounds, where significant cytotoxicity is seen in all normal and cancer cell lines. These data suggest a tumour-specific mechanism of action. In addition these data also show that spiroisoxazoline compounds are non-toxic in the human neuron-phenotypic neuroblastoma SH-SY5Y cell line, and furthermore that they might protect cells from neurodegenerative disease.
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spelling pubmed-62591572018-12-06 Evaluation of the Bioactivity of Novel Spiroisoxazoline Type Compounds against Normal and Cancer Cell Lines Najim, Nigar Bathich, Yaser Zain, Mazatulikhma Mat Hamzah, Ahmad Sazali Shaameri, Zurina Molecules Article The aim of this study was to investigate the in vitro cellular activity of novel spiroisoxazoline type compounds against normal and cancer cell lines from lung tissue (Hs888Lu), neuron-phenotypic cells (SH-SY5Y), neuroblastoma (SH-SY5Y), human histiocytic lymphoma (U937), lung cancer (A549), and leukaemia (HL-60). Our bioassay program revealed that the spiroisoxazoline type compounds show cytotoxicity only in lymphoma cell lines, which is in contrast with the pyrrolidine precursor of these spiroisoxazoline compounds, where significant cytotoxicity is seen in all normal and cancer cell lines. These data suggest a tumour-specific mechanism of action. In addition these data also show that spiroisoxazoline compounds are non-toxic in the human neuron-phenotypic neuroblastoma SH-SY5Y cell line, and furthermore that they might protect cells from neurodegenerative disease. MDPI 2010-12-17 /pmc/articles/PMC6259157/ /pubmed/21169884 http://dx.doi.org/10.3390/molecules15129340 Text en © 2010 by the authors; http://creativecommons.org/licenses/by/3.0/ licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Najim, Nigar
Bathich, Yaser
Zain, Mazatulikhma Mat
Hamzah, Ahmad Sazali
Shaameri, Zurina
Evaluation of the Bioactivity of Novel Spiroisoxazoline Type Compounds against Normal and Cancer Cell Lines
title Evaluation of the Bioactivity of Novel Spiroisoxazoline Type Compounds against Normal and Cancer Cell Lines
title_full Evaluation of the Bioactivity of Novel Spiroisoxazoline Type Compounds against Normal and Cancer Cell Lines
title_fullStr Evaluation of the Bioactivity of Novel Spiroisoxazoline Type Compounds against Normal and Cancer Cell Lines
title_full_unstemmed Evaluation of the Bioactivity of Novel Spiroisoxazoline Type Compounds against Normal and Cancer Cell Lines
title_short Evaluation of the Bioactivity of Novel Spiroisoxazoline Type Compounds against Normal and Cancer Cell Lines
title_sort evaluation of the bioactivity of novel spiroisoxazoline type compounds against normal and cancer cell lines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259157/
https://www.ncbi.nlm.nih.gov/pubmed/21169884
http://dx.doi.org/10.3390/molecules15129340
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