Synthesis of Seco-Chlorinated Derivatives of Phenanthroindolizidine Precursors via Friedel-Crafts Reaction

In the course of synthesizing 3-demethyltylophorine (1) by Lewis acid catalyzed intramolecular Friedel-Crafts reaction starting from N-(3-hydroxy-2,6,7-trimethoxy-phenanthr-9-ylmethyl)-2-chloromethylpyrrolidine, two chlorinated phenanthrene derivatives N-(4,10-dichloro-3-hydroxy-2,6,7-trimethoxyphen...

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Autores principales: Li, Songtao, Han, Li, Liu, Jiang, Hu, Yihan, Zheng, Dan, Fu, Yingbo, Huang, Xueshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259186/
https://www.ncbi.nlm.nih.gov/pubmed/21102376
http://dx.doi.org/10.3390/molecules15118501
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author Li, Songtao
Han, Li
Liu, Jiang
Hu, Yihan
Zheng, Dan
Fu, Yingbo
Huang, Xueshi
author_facet Li, Songtao
Han, Li
Liu, Jiang
Hu, Yihan
Zheng, Dan
Fu, Yingbo
Huang, Xueshi
author_sort Li, Songtao
collection PubMed
description In the course of synthesizing 3-demethyltylophorine (1) by Lewis acid catalyzed intramolecular Friedel-Crafts reaction starting from N-(3-hydroxy-2,6,7-trimethoxy-phenanthr-9-ylmethyl)-2-chloromethylpyrrolidine, two chlorinated phenanthrene derivatives N-(4,10-dichloro-3-hydroxy-2,6,7-trimethoxyphenanthr-9-ylmethyl)-2-chloromethylpyrrolidine (4) and N-(4-chloro-3-hydroxy-2,6,7-trimethoxyphenanthr-9-ylmethyl)-2-chloromethylpyrrolidine (5) were obtained. The structures of these compounds were determined by spectroscopic analysis.
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spelling pubmed-62591862018-12-06 Synthesis of Seco-Chlorinated Derivatives of Phenanthroindolizidine Precursors via Friedel-Crafts Reaction Li, Songtao Han, Li Liu, Jiang Hu, Yihan Zheng, Dan Fu, Yingbo Huang, Xueshi Molecules Communication In the course of synthesizing 3-demethyltylophorine (1) by Lewis acid catalyzed intramolecular Friedel-Crafts reaction starting from N-(3-hydroxy-2,6,7-trimethoxy-phenanthr-9-ylmethyl)-2-chloromethylpyrrolidine, two chlorinated phenanthrene derivatives N-(4,10-dichloro-3-hydroxy-2,6,7-trimethoxyphenanthr-9-ylmethyl)-2-chloromethylpyrrolidine (4) and N-(4-chloro-3-hydroxy-2,6,7-trimethoxyphenanthr-9-ylmethyl)-2-chloromethylpyrrolidine (5) were obtained. The structures of these compounds were determined by spectroscopic analysis. MDPI 2010-11-22 /pmc/articles/PMC6259186/ /pubmed/21102376 http://dx.doi.org/10.3390/molecules15118501 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Communication
Li, Songtao
Han, Li
Liu, Jiang
Hu, Yihan
Zheng, Dan
Fu, Yingbo
Huang, Xueshi
Synthesis of Seco-Chlorinated Derivatives of Phenanthroindolizidine Precursors via Friedel-Crafts Reaction
title Synthesis of Seco-Chlorinated Derivatives of Phenanthroindolizidine Precursors via Friedel-Crafts Reaction
title_full Synthesis of Seco-Chlorinated Derivatives of Phenanthroindolizidine Precursors via Friedel-Crafts Reaction
title_fullStr Synthesis of Seco-Chlorinated Derivatives of Phenanthroindolizidine Precursors via Friedel-Crafts Reaction
title_full_unstemmed Synthesis of Seco-Chlorinated Derivatives of Phenanthroindolizidine Precursors via Friedel-Crafts Reaction
title_short Synthesis of Seco-Chlorinated Derivatives of Phenanthroindolizidine Precursors via Friedel-Crafts Reaction
title_sort synthesis of seco-chlorinated derivatives of phenanthroindolizidine precursors via friedel-crafts reaction
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259186/
https://www.ncbi.nlm.nih.gov/pubmed/21102376
http://dx.doi.org/10.3390/molecules15118501
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