Alkaloids from Stems of Esenbeckia leiocarpa Engl. (Rutaceae) as Potential Treatment for Alzheimer Disease

Esenbeckia leiocarpa Engl. (Rutaceae), popularly known as guarantã, goiabeira, is a native tree from Brazil. Bioactivity-guided fractionation of the ethanol stems extract afforded the isolation of six alkaloids: leiokinine A, leptomerine, kokusaginine, skimmianine, maculine and flindersiamine. All i...

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Detalles Bibliográficos
Autores principales: Cardoso-Lopes, Elaine Monteiro, Maier, James Andreas, da Silva, Marcelo Rogério, Regasini, Luis Octávio, Simote, Simone Yasue, Lopes, Norberto Peporine, Pirani, José Rubens, Bolzani, Vanderlan da Silva, Young, Maria Cláudia Marx
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259197/
https://www.ncbi.nlm.nih.gov/pubmed/21160449
http://dx.doi.org/10.3390/molecules15129205
Descripción
Sumario:Esenbeckia leiocarpa Engl. (Rutaceae), popularly known as guarantã, goiabeira, is a native tree from Brazil. Bioactivity-guided fractionation of the ethanol stems extract afforded the isolation of six alkaloids: leiokinine A, leptomerine, kokusaginine, skimmianine, maculine and flindersiamine. All isolated compounds were tested for acetyl cholinesterase inhibition, in vitro and displayed anticholinesterasic activity. The alkaloid leptomerine showed the highest activity (IC(50) = 2.5 μM), similar to that of the reference compound galanthamine (IC(50) = 1.7 μM). The results showed for the first time the presence of alkaloids leptomerine and skimmianine in E. leiocarpa (Engl.) with potent anticholinesterasic activity.

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