Synthesis and Biological Activity of trans-Tiliroside Derivatives as Potent Anti-Diabetic Agents

A set of novel trans-tiliroside derivatives were synthesized. The structures of the derivatives were identified by their IR, (1)H-NMR, and MS spectra analysis. Their anti-diabetic activities were evaluated on the insulin resistant (IR) HepG2 cell model. As a result, compounds 7a, 7c, 7h, and trans-t...

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Detalles Bibliográficos
Autores principales: Zhu, Yujin, Zhang, Yanjun, Liu, Yi, Chu, Hongwan, Duan, Hongquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259203/
https://www.ncbi.nlm.nih.gov/pubmed/21150832
http://dx.doi.org/10.3390/molecules15129174
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author Zhu, Yujin
Zhang, Yanjun
Liu, Yi
Chu, Hongwan
Duan, Hongquan
author_facet Zhu, Yujin
Zhang, Yanjun
Liu, Yi
Chu, Hongwan
Duan, Hongquan
author_sort Zhu, Yujin
collection PubMed
description A set of novel trans-tiliroside derivatives were synthesized. The structures of the derivatives were identified by their IR, (1)H-NMR, and MS spectra analysis. Their anti-diabetic activities were evaluated on the insulin resistant (IR) HepG2 cell model. As a result, compounds 7a, 7c, 7h, and trans-tiliroside exhibited significant glucose consumption-enhancing effects in IR-HepG2 cells compared with the positive control (metformin). This research provides useful clues for further design and discovery of anti-diabetic agents.
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spelling pubmed-62592032018-12-06 Synthesis and Biological Activity of trans-Tiliroside Derivatives as Potent Anti-Diabetic Agents Zhu, Yujin Zhang, Yanjun Liu, Yi Chu, Hongwan Duan, Hongquan Molecules Article A set of novel trans-tiliroside derivatives were synthesized. The structures of the derivatives were identified by their IR, (1)H-NMR, and MS spectra analysis. Their anti-diabetic activities were evaluated on the insulin resistant (IR) HepG2 cell model. As a result, compounds 7a, 7c, 7h, and trans-tiliroside exhibited significant glucose consumption-enhancing effects in IR-HepG2 cells compared with the positive control (metformin). This research provides useful clues for further design and discovery of anti-diabetic agents. MDPI 2010-12-10 /pmc/articles/PMC6259203/ /pubmed/21150832 http://dx.doi.org/10.3390/molecules15129174 Text en © 2010 by the authors; http://creativecommons.org/licenses/by/3.0/ licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Zhu, Yujin
Zhang, Yanjun
Liu, Yi
Chu, Hongwan
Duan, Hongquan
Synthesis and Biological Activity of trans-Tiliroside Derivatives as Potent Anti-Diabetic Agents
title Synthesis and Biological Activity of trans-Tiliroside Derivatives as Potent Anti-Diabetic Agents
title_full Synthesis and Biological Activity of trans-Tiliroside Derivatives as Potent Anti-Diabetic Agents
title_fullStr Synthesis and Biological Activity of trans-Tiliroside Derivatives as Potent Anti-Diabetic Agents
title_full_unstemmed Synthesis and Biological Activity of trans-Tiliroside Derivatives as Potent Anti-Diabetic Agents
title_short Synthesis and Biological Activity of trans-Tiliroside Derivatives as Potent Anti-Diabetic Agents
title_sort synthesis and biological activity of trans-tiliroside derivatives as potent anti-diabetic agents
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259203/
https://www.ncbi.nlm.nih.gov/pubmed/21150832
http://dx.doi.org/10.3390/molecules15129174
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