Unexplored Nucleophilic Ring Opening of Aziridines †

The reactivity of dianions of carboxylic acids towards aziridines has been studied. Although, a similar reactivity to that of enolates from ketones, esters or amides has been observed, the method directly yields γ-aminoacids in one step. The method is complementary of previous results of enenediolat...

Descripción completa

Detalles Bibliográficos
Autores principales: Costero, Ana María, Gil, Salvador, Parra, Margarita, Rodríguez, Pablo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259205/
https://www.ncbi.nlm.nih.gov/pubmed/21150827
http://dx.doi.org/10.3390/molecules15129135
_version_ 1783374633133670400
author Costero, Ana María
Gil, Salvador
Parra, Margarita
Rodríguez, Pablo
author_facet Costero, Ana María
Gil, Salvador
Parra, Margarita
Rodríguez, Pablo
author_sort Costero, Ana María
collection PubMed
description The reactivity of dianions of carboxylic acids towards aziridines has been studied. Although, a similar reactivity to that of enolates from ketones, esters or amides has been observed, the method directly yields γ-aminoacids in one step. The method is complementary of previous results of enenediolate reactivity with other electrophiles. A comparative study with the reactivity of this enediolates with epoxides is included.
format Online
Article
Text
id pubmed-6259205
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62592052018-12-06 Unexplored Nucleophilic Ring Opening of Aziridines † Costero, Ana María Gil, Salvador Parra, Margarita Rodríguez, Pablo Molecules Article The reactivity of dianions of carboxylic acids towards aziridines has been studied. Although, a similar reactivity to that of enolates from ketones, esters or amides has been observed, the method directly yields γ-aminoacids in one step. The method is complementary of previous results of enenediolate reactivity with other electrophiles. A comparative study with the reactivity of this enediolates with epoxides is included. MDPI 2010-12-10 /pmc/articles/PMC6259205/ /pubmed/21150827 http://dx.doi.org/10.3390/molecules15129135 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Costero, Ana María
Gil, Salvador
Parra, Margarita
Rodríguez, Pablo
Unexplored Nucleophilic Ring Opening of Aziridines †
title Unexplored Nucleophilic Ring Opening of Aziridines †
title_full Unexplored Nucleophilic Ring Opening of Aziridines †
title_fullStr Unexplored Nucleophilic Ring Opening of Aziridines †
title_full_unstemmed Unexplored Nucleophilic Ring Opening of Aziridines †
title_short Unexplored Nucleophilic Ring Opening of Aziridines †
title_sort unexplored nucleophilic ring opening of aziridines †
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259205/
https://www.ncbi.nlm.nih.gov/pubmed/21150827
http://dx.doi.org/10.3390/molecules15129135
work_keys_str_mv AT costeroanamaria unexplorednucleophilicringopeningofaziridines
AT gilsalvador unexplorednucleophilicringopeningofaziridines
AT parramargarita unexplorednucleophilicringopeningofaziridines
AT rodriguezpablo unexplorednucleophilicringopeningofaziridines

Ejemplares similares