Design and Synthesis of Anti-MRSA Benzimidazolylbenzene-sulfonamides. QSAR Studies for Prediction of Antibacterial Activity

A series of benzimidazolylbenzenesulfonamide compounds containing electron-releasing and electron-withdrawing substituents were synthesized and tested for their in vitro antibacterial activity. Two BZS compounds showed strong antibacterial activity against methicillin-resistant Staphylococcus aureus...

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Autores principales: González-Chávez, Marco Martín, Méndez, Francisco, Martínez, Roberto, Pérez-González, Cuaúhtemoc, Martínez-Gutiérrez, Fidel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259222/
https://www.ncbi.nlm.nih.gov/pubmed/21191320
http://dx.doi.org/10.3390/molecules16010175
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author González-Chávez, Marco Martín
Méndez, Francisco
Martínez, Roberto
Pérez-González, Cuaúhtemoc
Martínez-Gutiérrez, Fidel
author_facet González-Chávez, Marco Martín
Méndez, Francisco
Martínez, Roberto
Pérez-González, Cuaúhtemoc
Martínez-Gutiérrez, Fidel
author_sort González-Chávez, Marco Martín
collection PubMed
description A series of benzimidazolylbenzenesulfonamide compounds containing electron-releasing and electron-withdrawing substituents were synthesized and tested for their in vitro antibacterial activity. Two BZS compounds showed strong antibacterial activity against methicillin-resistant Staphylococcus aureus and Bacillus subtilis. Quantitative studies of their structure-activity relationship using a simple linear regression analysis were applied to explore the correlation between the biological activity and the charges on acidic hydrogen atoms in the synthesized compounds.
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spelling pubmed-62592222018-12-07 Design and Synthesis of Anti-MRSA Benzimidazolylbenzene-sulfonamides. QSAR Studies for Prediction of Antibacterial Activity González-Chávez, Marco Martín Méndez, Francisco Martínez, Roberto Pérez-González, Cuaúhtemoc Martínez-Gutiérrez, Fidel Molecules Article A series of benzimidazolylbenzenesulfonamide compounds containing electron-releasing and electron-withdrawing substituents were synthesized and tested for their in vitro antibacterial activity. Two BZS compounds showed strong antibacterial activity against methicillin-resistant Staphylococcus aureus and Bacillus subtilis. Quantitative studies of their structure-activity relationship using a simple linear regression analysis were applied to explore the correlation between the biological activity and the charges on acidic hydrogen atoms in the synthesized compounds. MDPI 2010-12-29 /pmc/articles/PMC6259222/ /pubmed/21191320 http://dx.doi.org/10.3390/molecules16010175 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
González-Chávez, Marco Martín
Méndez, Francisco
Martínez, Roberto
Pérez-González, Cuaúhtemoc
Martínez-Gutiérrez, Fidel
Design and Synthesis of Anti-MRSA Benzimidazolylbenzene-sulfonamides. QSAR Studies for Prediction of Antibacterial Activity
title Design and Synthesis of Anti-MRSA Benzimidazolylbenzene-sulfonamides. QSAR Studies for Prediction of Antibacterial Activity
title_full Design and Synthesis of Anti-MRSA Benzimidazolylbenzene-sulfonamides. QSAR Studies for Prediction of Antibacterial Activity
title_fullStr Design and Synthesis of Anti-MRSA Benzimidazolylbenzene-sulfonamides. QSAR Studies for Prediction of Antibacterial Activity
title_full_unstemmed Design and Synthesis of Anti-MRSA Benzimidazolylbenzene-sulfonamides. QSAR Studies for Prediction of Antibacterial Activity
title_short Design and Synthesis of Anti-MRSA Benzimidazolylbenzene-sulfonamides. QSAR Studies for Prediction of Antibacterial Activity
title_sort design and synthesis of anti-mrsa benzimidazolylbenzene-sulfonamides. qsar studies for prediction of antibacterial activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259222/
https://www.ncbi.nlm.nih.gov/pubmed/21191320
http://dx.doi.org/10.3390/molecules16010175
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