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New Anti-Inflammatory and Anti-Proliferative Constituents from Fermented Red Mold Rice Monascus purpureus NTU 568

Six azaphilonoid derivatives, including two new blue fluorescent monapurfluores A (1) and B (2), two known pyridine-containing molecules, monascopyridines C (3) and D (4), and two known monasfluores A (5) and B (6), were isolated and characterized from red mold rice fermented by Monascus purpureus N...

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Autores principales: Hsu, Ya-Wen, Hsu, Li-Chuan, Chang, Chao-Lin, Liang, Yu-Han, Kuo, Yao-Haur, Pan, Tzu-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259223/
https://www.ncbi.nlm.nih.gov/pubmed/21060290
http://dx.doi.org/10.3390/molecules15117815
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author Hsu, Ya-Wen
Hsu, Li-Chuan
Chang, Chao-Lin
Liang, Yu-Han
Kuo, Yao-Haur
Pan, Tzu-Ming
author_facet Hsu, Ya-Wen
Hsu, Li-Chuan
Chang, Chao-Lin
Liang, Yu-Han
Kuo, Yao-Haur
Pan, Tzu-Ming
author_sort Hsu, Ya-Wen
collection PubMed
description Six azaphilonoid derivatives, including two new blue fluorescent monapurfluores A (1) and B (2), two known pyridine-containing molecules, monascopyridines C (3) and D (4), and two known monasfluores A (5) and B (6), were isolated and characterized from red mold rice fermented by Monascus purpureus NTU 568. Structural elucidation of new isolates was based on nuclear magnetic resonance ((1)H- NMR, (13)C-NMR, COSY, HMQC, and HMBC) and other spectroscopic analyses. Bioactivity evaluation indicated that 1-6 possessed anti-inflammatory activities with dose-dependent relationships for lipopolysaccharide (LPS)-induced nitric oxide production. Furthermore, 1-4 also showed moderate antiproliferative effects against human laryngeal carcinoma (HEp-2) (IC(50) = 14.81~20.06 μg/mL) and human colon adenocarcinoma (WiDr) (IC(50) = 12.89~21.14 μg/mL).
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spelling pubmed-62592232018-12-06 New Anti-Inflammatory and Anti-Proliferative Constituents from Fermented Red Mold Rice Monascus purpureus NTU 568 Hsu, Ya-Wen Hsu, Li-Chuan Chang, Chao-Lin Liang, Yu-Han Kuo, Yao-Haur Pan, Tzu-Ming Molecules Article Six azaphilonoid derivatives, including two new blue fluorescent monapurfluores A (1) and B (2), two known pyridine-containing molecules, monascopyridines C (3) and D (4), and two known monasfluores A (5) and B (6), were isolated and characterized from red mold rice fermented by Monascus purpureus NTU 568. Structural elucidation of new isolates was based on nuclear magnetic resonance ((1)H- NMR, (13)C-NMR, COSY, HMQC, and HMBC) and other spectroscopic analyses. Bioactivity evaluation indicated that 1-6 possessed anti-inflammatory activities with dose-dependent relationships for lipopolysaccharide (LPS)-induced nitric oxide production. Furthermore, 1-4 also showed moderate antiproliferative effects against human laryngeal carcinoma (HEp-2) (IC(50) = 14.81~20.06 μg/mL) and human colon adenocarcinoma (WiDr) (IC(50) = 12.89~21.14 μg/mL). MDPI 2010-11-03 /pmc/articles/PMC6259223/ /pubmed/21060290 http://dx.doi.org/10.3390/molecules15117815 Text en © 2010 by the authors; http://creativecommons.org/licenses/by/3.0/ licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Hsu, Ya-Wen
Hsu, Li-Chuan
Chang, Chao-Lin
Liang, Yu-Han
Kuo, Yao-Haur
Pan, Tzu-Ming
New Anti-Inflammatory and Anti-Proliferative Constituents from Fermented Red Mold Rice Monascus purpureus NTU 568
title New Anti-Inflammatory and Anti-Proliferative Constituents from Fermented Red Mold Rice Monascus purpureus NTU 568
title_full New Anti-Inflammatory and Anti-Proliferative Constituents from Fermented Red Mold Rice Monascus purpureus NTU 568
title_fullStr New Anti-Inflammatory and Anti-Proliferative Constituents from Fermented Red Mold Rice Monascus purpureus NTU 568
title_full_unstemmed New Anti-Inflammatory and Anti-Proliferative Constituents from Fermented Red Mold Rice Monascus purpureus NTU 568
title_short New Anti-Inflammatory and Anti-Proliferative Constituents from Fermented Red Mold Rice Monascus purpureus NTU 568
title_sort new anti-inflammatory and anti-proliferative constituents from fermented red mold rice monascus purpureus ntu 568
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259223/
https://www.ncbi.nlm.nih.gov/pubmed/21060290
http://dx.doi.org/10.3390/molecules15117815
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