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Acute Oral Toxicity and Brine Shrimp Lethality of Elaeis guineensis Jacq., (Oil Palm Leaf) Methanol Extract
Elaeis guineensis (Arecaceae) is widely used in West African traditional medicine for treating various ailments. An evaluation on the toxicity of extracts of this plant is crucial to support the therapeutic claims. The acute oral toxicity and brine shrimp lethality of a methanolic extract of this pl...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259233/ https://www.ncbi.nlm.nih.gov/pubmed/21072022 http://dx.doi.org/10.3390/molecules15118111 |
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author | Syahmi, Abdul Rani Muhamad Vijayaratna, Soundararajan Sasidharan, Sreenivasan Latha, Lachimanan Yoga Kwan, Yuet Ping Lau, Yee Ling Shin, Lai Ngit Chen, Yeng |
author_facet | Syahmi, Abdul Rani Muhamad Vijayaratna, Soundararajan Sasidharan, Sreenivasan Latha, Lachimanan Yoga Kwan, Yuet Ping Lau, Yee Ling Shin, Lai Ngit Chen, Yeng |
author_sort | Syahmi, Abdul Rani Muhamad |
collection | PubMed |
description | Elaeis guineensis (Arecaceae) is widely used in West African traditional medicine for treating various ailments. An evaluation on the toxicity of extracts of this plant is crucial to support the therapeutic claims. The acute oral toxicity and brine shrimp lethality of a methanolic extract of this plant was tested. Oral administration of crude extract at the highest dose of 5,000 mg/kg resulted in no mortalities or evidence of adverse effects, implying that E. guineensis is nontoxic. Normal behavioral pattern, clinical signs and histology of vital organs confirm this evidence. The E. guineensis extracts screened for toxicity against brine shrimp had 50% lethal concentration (LC(50)) values of more than 1.0 mg/mL (9.00 and 3.87 mg/mL, at 6 and 24 h, respectively), confirming that the extract was not toxic. Maximum mortalities occurred at 100 mg/mL concentration while the least mortalities happened to be at 0.195 mg/mL concentration. The results of both tests confirm that E. guineensis is nontoxic and hence safe for commercial utilization. |
format | Online Article Text |
id | pubmed-6259233 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62592332018-12-06 Acute Oral Toxicity and Brine Shrimp Lethality of Elaeis guineensis Jacq., (Oil Palm Leaf) Methanol Extract Syahmi, Abdul Rani Muhamad Vijayaratna, Soundararajan Sasidharan, Sreenivasan Latha, Lachimanan Yoga Kwan, Yuet Ping Lau, Yee Ling Shin, Lai Ngit Chen, Yeng Molecules Article Elaeis guineensis (Arecaceae) is widely used in West African traditional medicine for treating various ailments. An evaluation on the toxicity of extracts of this plant is crucial to support the therapeutic claims. The acute oral toxicity and brine shrimp lethality of a methanolic extract of this plant was tested. Oral administration of crude extract at the highest dose of 5,000 mg/kg resulted in no mortalities or evidence of adverse effects, implying that E. guineensis is nontoxic. Normal behavioral pattern, clinical signs and histology of vital organs confirm this evidence. The E. guineensis extracts screened for toxicity against brine shrimp had 50% lethal concentration (LC(50)) values of more than 1.0 mg/mL (9.00 and 3.87 mg/mL, at 6 and 24 h, respectively), confirming that the extract was not toxic. Maximum mortalities occurred at 100 mg/mL concentration while the least mortalities happened to be at 0.195 mg/mL concentration. The results of both tests confirm that E. guineensis is nontoxic and hence safe for commercial utilization. MDPI 2010-11-10 /pmc/articles/PMC6259233/ /pubmed/21072022 http://dx.doi.org/10.3390/molecules15118111 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Syahmi, Abdul Rani Muhamad Vijayaratna, Soundararajan Sasidharan, Sreenivasan Latha, Lachimanan Yoga Kwan, Yuet Ping Lau, Yee Ling Shin, Lai Ngit Chen, Yeng Acute Oral Toxicity and Brine Shrimp Lethality of Elaeis guineensis Jacq., (Oil Palm Leaf) Methanol Extract |
title | Acute Oral Toxicity and Brine Shrimp Lethality of Elaeis guineensis Jacq., (Oil Palm Leaf) Methanol Extract |
title_full | Acute Oral Toxicity and Brine Shrimp Lethality of Elaeis guineensis Jacq., (Oil Palm Leaf) Methanol Extract |
title_fullStr | Acute Oral Toxicity and Brine Shrimp Lethality of Elaeis guineensis Jacq., (Oil Palm Leaf) Methanol Extract |
title_full_unstemmed | Acute Oral Toxicity and Brine Shrimp Lethality of Elaeis guineensis Jacq., (Oil Palm Leaf) Methanol Extract |
title_short | Acute Oral Toxicity and Brine Shrimp Lethality of Elaeis guineensis Jacq., (Oil Palm Leaf) Methanol Extract |
title_sort | acute oral toxicity and brine shrimp lethality of elaeis guineensis jacq., (oil palm leaf) methanol extract |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259233/ https://www.ncbi.nlm.nih.gov/pubmed/21072022 http://dx.doi.org/10.3390/molecules15118111 |
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