Synthesis and Antitumor Activity of 3-Methyl-4-oxo-3,4-dihydroimidazo [5,1-d][1,2,3,5]tetrazine-8-carboxylates and -carboxamides

Seventeen novel 3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylate and -carboxamide derivatives were synthesized and evaluated for their growth inhibition in seven human solid tumor and a human leukemia HL-60 cell lines. Compound IVa showed more activity than the other compound...

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Detalles Bibliográficos
Autores principales: Liu, Dan, Yang, Jian-Guo, Cheng, Jie, Zhao, Lin-Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259238/
https://www.ncbi.nlm.nih.gov/pubmed/21173727
http://dx.doi.org/10.3390/molecules15129427

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259238/
https://www.ncbi.nlm.nih.gov/pubmed/21173727
http://dx.doi.org/10.3390/molecules15129427

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