Synthesis 1-Acyl-3-(2'-aminophenyl) thioureas as Anti-Intestinal Nematode Prodrugs

A series of 1-acyl-3-(2'-aminophenyl) thiourea derivatives were designed and synthesized. The structures of all the newly synthesized compounds were identified by IR, elemental analysis, (1)H-NMR and (13)C-NMR. Their anti-intestinal nematode activities against Nippostrongylus brazilliensis were...

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Detalles Bibliográficos
Autores principales: Duan, Li-Ping, Xue, Jia, Xu, Li-Li, Zhang, Hao-Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259247/
https://www.ncbi.nlm.nih.gov/pubmed/20938404
http://dx.doi.org/10.3390/molecules15106941
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author Duan, Li-Ping
Xue, Jia
Xu, Li-Li
Zhang, Hao-Bing
author_facet Duan, Li-Ping
Xue, Jia
Xu, Li-Li
Zhang, Hao-Bing
author_sort Duan, Li-Ping
collection PubMed
description A series of 1-acyl-3-(2'-aminophenyl) thiourea derivatives were designed and synthesized. The structures of all the newly synthesized compounds were identified by IR, elemental analysis, (1)H-NMR and (13)C-NMR. Their anti-intestinal nematode activities against Nippostrongylus brazilliensis were evaluated in rats by an oral route. Among these compounds, at concentrations of 10 mg/kg of rat, compound (1-(2'-furanyl)acyl-3- (2'-aminophenyl) thiourea) (5h) produced the highest activity with 89.4% deparasitization. The present work suggests that 1-acyl-3-(2'-aminophenyl) thiourea derivatives may become useful lead compounds for anti-intestinal nematode treatment.
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spelling pubmed-62592472018-12-06 Synthesis 1-Acyl-3-(2'-aminophenyl) thioureas as Anti-Intestinal Nematode Prodrugs Duan, Li-Ping Xue, Jia Xu, Li-Li Zhang, Hao-Bing Molecules Article A series of 1-acyl-3-(2'-aminophenyl) thiourea derivatives were designed and synthesized. The structures of all the newly synthesized compounds were identified by IR, elemental analysis, (1)H-NMR and (13)C-NMR. Their anti-intestinal nematode activities against Nippostrongylus brazilliensis were evaluated in rats by an oral route. Among these compounds, at concentrations of 10 mg/kg of rat, compound (1-(2'-furanyl)acyl-3- (2'-aminophenyl) thiourea) (5h) produced the highest activity with 89.4% deparasitization. The present work suggests that 1-acyl-3-(2'-aminophenyl) thiourea derivatives may become useful lead compounds for anti-intestinal nematode treatment. MDPI 2010-10-08 /pmc/articles/PMC6259247/ /pubmed/20938404 http://dx.doi.org/10.3390/molecules15106941 Text en © 2010 by the authors; http://creativecommons.org/licenses/by/3.0/ licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Duan, Li-Ping
Xue, Jia
Xu, Li-Li
Zhang, Hao-Bing
Synthesis 1-Acyl-3-(2'-aminophenyl) thioureas as Anti-Intestinal Nematode Prodrugs
title Synthesis 1-Acyl-3-(2'-aminophenyl) thioureas as Anti-Intestinal Nematode Prodrugs
title_full Synthesis 1-Acyl-3-(2'-aminophenyl) thioureas as Anti-Intestinal Nematode Prodrugs
title_fullStr Synthesis 1-Acyl-3-(2'-aminophenyl) thioureas as Anti-Intestinal Nematode Prodrugs
title_full_unstemmed Synthesis 1-Acyl-3-(2'-aminophenyl) thioureas as Anti-Intestinal Nematode Prodrugs
title_short Synthesis 1-Acyl-3-(2'-aminophenyl) thioureas as Anti-Intestinal Nematode Prodrugs
title_sort synthesis 1-acyl-3-(2'-aminophenyl) thioureas as anti-intestinal nematode prodrugs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259247/
https://www.ncbi.nlm.nih.gov/pubmed/20938404
http://dx.doi.org/10.3390/molecules15106941
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