Synthesis of Benzofuran Derivatives via Rearrangement and Their Inhibitory Activity on Acetylcholinesterase

During a synthesis of coumarins to obtain new candidates for treating Alzheimer’s Disease (AD), an unusual rearrangement of a benzopyran group to a benzofuran group occurred, offering a novel synthesis pathway of these benzofuran derivatives. The possible mechanism of the novel rearrangement was als...

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Detalles Bibliográficos
Autores principales: Zhou, Xiang, Li, Miao, Wang, Xiao-Bing, Wang, Tao, Kong, Ling-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259253/
https://www.ncbi.nlm.nih.gov/pubmed/21116228
http://dx.doi.org/10.3390/molecules15128593
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author Zhou, Xiang
Li, Miao
Wang, Xiao-Bing
Wang, Tao
Kong, Ling-Yi
author_facet Zhou, Xiang
Li, Miao
Wang, Xiao-Bing
Wang, Tao
Kong, Ling-Yi
author_sort Zhou, Xiang
collection PubMed
description During a synthesis of coumarins to obtain new candidates for treating Alzheimer’s Disease (AD), an unusual rearrangement of a benzopyran group to a benzofuran group occurred, offering a novel synthesis pathway of these benzofuran derivatives. The possible mechanism of the novel rearrangement was also discussed. All of the benzofuran derivatives have weak anti-AChE activities compared with the reference compound, donepezil.
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spelling pubmed-62592532018-12-06 Synthesis of Benzofuran Derivatives via Rearrangement and Their Inhibitory Activity on Acetylcholinesterase Zhou, Xiang Li, Miao Wang, Xiao-Bing Wang, Tao Kong, Ling-Yi Molecules Article During a synthesis of coumarins to obtain new candidates for treating Alzheimer’s Disease (AD), an unusual rearrangement of a benzopyran group to a benzofuran group occurred, offering a novel synthesis pathway of these benzofuran derivatives. The possible mechanism of the novel rearrangement was also discussed. All of the benzofuran derivatives have weak anti-AChE activities compared with the reference compound, donepezil. MDPI 2010-11-29 /pmc/articles/PMC6259253/ /pubmed/21116228 http://dx.doi.org/10.3390/molecules15128593 Text en © 2010 by the authors; http://creativecommons.org/licenses/by/3.0/ licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Zhou, Xiang
Li, Miao
Wang, Xiao-Bing
Wang, Tao
Kong, Ling-Yi
Synthesis of Benzofuran Derivatives via Rearrangement and Their Inhibitory Activity on Acetylcholinesterase
title Synthesis of Benzofuran Derivatives via Rearrangement and Their Inhibitory Activity on Acetylcholinesterase
title_full Synthesis of Benzofuran Derivatives via Rearrangement and Their Inhibitory Activity on Acetylcholinesterase
title_fullStr Synthesis of Benzofuran Derivatives via Rearrangement and Their Inhibitory Activity on Acetylcholinesterase
title_full_unstemmed Synthesis of Benzofuran Derivatives via Rearrangement and Their Inhibitory Activity on Acetylcholinesterase
title_short Synthesis of Benzofuran Derivatives via Rearrangement and Their Inhibitory Activity on Acetylcholinesterase
title_sort synthesis of benzofuran derivatives via rearrangement and their inhibitory activity on acetylcholinesterase
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259253/
https://www.ncbi.nlm.nih.gov/pubmed/21116228
http://dx.doi.org/10.3390/molecules15128593
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