Synthesis and Reactivity of [1,2,4]Triazolo-annelated Quinazolines

This paper reports the synthesis of phenyl-substituted 2-alkoxy(methylsulfanyl)-1,2,4-triazolo[1,5-a]quinazolines starting from N-cyanoimidocarbonates and substituted hydrazinobenzoic acids as building blocks. Thionation or chlorination of the inherent lactam moiety in the target compounds followed...

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Detalles Bibliográficos
Autor principal: Al-Salahi, Rashad A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259257/
http://dx.doi.org/10.3390/molecules15107016
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author Al-Salahi, Rashad A.
author_facet Al-Salahi, Rashad A.
author_sort Al-Salahi, Rashad A.
collection PubMed
description This paper reports the synthesis of phenyl-substituted 2-alkoxy(methylsulfanyl)-1,2,4-triazolo[1,5-a]quinazolines starting from N-cyanoimidocarbonates and substituted hydrazinobenzoic acids as building blocks. Thionation or chlorination of the inherent lactam moiety in the target compounds followed by treatment with multifunctional nucleophiles provided access to a variety of derivatives.
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spelling pubmed-62592572018-12-06 Synthesis and Reactivity of [1,2,4]Triazolo-annelated Quinazolines Al-Salahi, Rashad A. Molecules Article This paper reports the synthesis of phenyl-substituted 2-alkoxy(methylsulfanyl)-1,2,4-triazolo[1,5-a]quinazolines starting from N-cyanoimidocarbonates and substituted hydrazinobenzoic acids as building blocks. Thionation or chlorination of the inherent lactam moiety in the target compounds followed by treatment with multifunctional nucleophiles provided access to a variety of derivatives. MDPI 2010-10-12 /pmc/articles/PMC6259257/ http://dx.doi.org/10.3390/molecules15107016 Text en © 2010 by the authors; http://creativecommons.org/licenses/by/3.0/ licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Al-Salahi, Rashad A.
Synthesis and Reactivity of [1,2,4]Triazolo-annelated Quinazolines
title Synthesis and Reactivity of [1,2,4]Triazolo-annelated Quinazolines
title_full Synthesis and Reactivity of [1,2,4]Triazolo-annelated Quinazolines
title_fullStr Synthesis and Reactivity of [1,2,4]Triazolo-annelated Quinazolines
title_full_unstemmed Synthesis and Reactivity of [1,2,4]Triazolo-annelated Quinazolines
title_short Synthesis and Reactivity of [1,2,4]Triazolo-annelated Quinazolines
title_sort synthesis and reactivity of [1,2,4]triazolo-annelated quinazolines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259257/
http://dx.doi.org/10.3390/molecules15107016
work_keys_str_mv AT alsalahirashada synthesisandreactivityof124triazoloannelatedquinazolines

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