Cargando…

Synthesis and Reactivity of [1,2,4]Triazolo-annelated Quinazolines

This paper reports the synthesis of phenyl-substituted 2-alkoxy(methylsulfanyl)-1,2,4-triazolo[1,5-a]quinazolines starting from N-cyanoimidocarbonates and substituted hydrazinobenzoic acids as building blocks. Thionation or chlorination of the inherent lactam moiety in the target compounds followed...

Descripción completa

Detalles Bibliográficos
Autor principal:	Al-Salahi, Rashad A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259257/ http://dx.doi.org/10.3390/molecules15107016

Ejemplares similares

Al-Salahi, R. Synthesis and Reactivity of [1,2,4]Triazolo-annelated Quinazolines. Molecules 2010, 15, 7016–7034
por: Al-Salahi, Rashad A., et al.
Publicado: (2010)

5-Chloro-2-methylsulfonyl-1,2,4-triazolo[1,5-a]quinazoline
por: Al-Salahi, Rashad, et al.
Publicado: (2012)

2-Benzyloxy-1,2,4-triazolo[1,5-a]quinazolin-5(4H)-one
por: Al-Salahi, Rashad, et al.
Publicado: (2011)

2-Benzyloxy-1,2,4-triazolo[1,5-a]quinazolin-5(4H)-one. Corrigendum
por: Al-Salahi, Rashad, et al.
Publicado: (2011)

2-Ethoxy-5-methylbis[1,2,4]triazolo[1,5-a:4′,3′-c]quinazoline
por: Al-Salahi, Rashad, et al.
Publicado: (2011)

2-Methylsulfanyl-1,2,4-triazolo[1,5-a]quinazolin-5(4H)-one
por: Al-Salahi, Rashad, et al.
Publicado: (2012)

2-Phenoxy-1,2,4-triazolo[1,5-a]quinazolin-5(4H)-one
por: Al-Salahi, Rashad, et al.
Publicado: (2012)

2-Methylsulfonyl-1,2,4-triazolo[1,5-a]quinazolin-5(4H)-one
por: Al-Salahi, Rashad, et al.
Publicado: (2012)

2-Methylsulfanyl-1,2,4-triazolo[1,5-a]quinazoline-5(4H)-thione
por: Al-Salahi, Rashad, et al.
Publicado: (2013)

Biological effects of a new set 1,2,4-triazolo[1,5-a]quinazolines on heart rate and blood pressure
por: Al-Salahi, Rashad, et al.
Publicado: (2014)

Design, Synthesis, and Antimicrobial Evaluation of New Annelated Pyrimido[2,1-c][1,2,4]triazolo[3,4-f][1,2,4]triazines
por: El Azab, Islam H., et al.
Publicado: (2020)

3-Aryl-5-aminobiphenyl Substituted [1,2,4]triazolo[4,3-c]quinazolines: Synthesis and Photophysical Properties
por: Kopotilova, Alexandra E., et al.
Publicado: (2023)

Synthesis and Anticancer Activity of 2-(Alkyl-, Alkaryl-, Aryl-, Hetaryl-)-[1,2,4]triazolo[1,5-c]quinazolines
por: Kovalenko, Sergiy I., et al.
Publicado: (2013)

Angular Regioselective Synthesis of Varied Functionalized Hexahydro-1,2,4-triazolo[4,3-a]quinazolin-9-ones and Their Antiproliferative Action †
por: Said, Awad I., et al.
Publicado: (2023)

New [1,2,4]triazolo[4,3-c]quinazolines as intercalative Topo II inhibitors: Design, synthesis, biological evaluation, and in silico studies
por: Gaber, Ahmed A., et al.
Publicado: (2023)

Synthesis and anticancer activity of new quinazoline derivatives
por: Abuelizz, Hatem A., et al.
Publicado: (2017)

5,6,7,8-Tetrahydro-[1,2,4]triazolo[5,1-b]quinazolin-9(4H)-one
por: Ettahiri, Walid, et al.
Publicado: (2023)

Synthesis, biological activity and molecular modeling study of novel 1,2,4-triazolo[4,3-b][1,2,4,5]tetrazines and 1,2,4-triazolo[4,3-b][1,2,4]triazines
por: El-Reedy, Ahmed A. M., et al.
Publicado: (2020)

Angular Regioselectivity in the Reactions of 2-Thioxopyrimidin-4-ones and Hydrazonoyl Chlorides: Synthesis of Novel Stereoisomeric Octahydro[1,2,4]triazolo[4,3-a]quinazolin-5-ones
por: Said, Awad I., et al.
Publicado: (2020)

Synthesis of pyrido-annelated [1,2,4,5]tetrazines, [1,2,4]triazepine, and [1,2,4,5]tetrazepines for anticancer, DFT, and molecular docking studies
por: Hassan, Aisha Y., et al.
Publicado: (2023)

3-(Prop-2-en-1-yl)-2-sulfanylidene-1,2,3,4-tetrahydroquinazolin-4-one
por: Al-Salahi, Rashad, et al.
Publicado: (2012)

3-Benzyl-8-methoxy-2-sulfanylidene-1,2,3,4-tetrahydroquinazolin-4-one
por: Al-Salahi, Rashad, et al.
Publicado: (2012)

Novel [1,2,4]triazolo[3,4-b][1,3,4]thiadiazine and [1,2,4]triazolo[3,4-b][1,3,4]thiadiazepine Derivatives: Synthesis, Anti-Viral In Vitro Study and Target Validation Activity
por: Khramchikhin, Andrey V., et al.
Publicado: (2022)

Synthesis, Characterization, Antibacterial, Antifungal and Anticorrosion Activities of 1,2,4-Triazolo[1,5-a]quinazolinone
por: Ettahiri, Walid, et al.
Publicado: (2023)

3-Methyl-1,2,4-triazolo[3,4-a]phthalazine monohydrate
por: Dutkiewicz, Grzegorz, et al.
Publicado: (2009)

Regioselectivity of Electrophilic Attack on 4-Methyl-1-thioxo- 1,2,4,5-tetrahydro[1,2,4]triazolo[4,3-a]quinazolin-5-one. Part 1: Reactions at the Sulfur Atom
por: Fathalla, Walid, et al.
Publicado: (2001)

[1,2,4]Triazolo[4,3-a]phthalazines: Inhibitors of Diverse Bromodomains
por: Fedorov, Oleg, et al.
Publicado: (2013)

Synthesis and Electrophilic Substitutions of Novel Pyrazolo[1,5-c]-1,2,4-triazolo[4,3-a]pyrimidines
por: Atta, Kamal F.M.
Publicado: (2011)

Synthesis of novel [1,2,4]triazolo[1,5-b][1,2,4,5]tetrazines and investigation of their fungistatic activity
por: Korotina, Anna V, et al.
Publicado: (2022)

Three Component One-Pot Synthesis and Antiproliferative Activity of New [1,2,4]Triazolo[4,3-a]pyrimidines
por: Ben Hassen, Manel, et al.
Publicado: (2023)

Synthesis and Biological Evaluation of Some [1,2,4]Triazolo[4,3-a]quinoxaline Derivatives as Novel Anticonvulsant Agents
por: Alswah, Mohamed, et al.
Publicado: (2013)

Molecular docking study and antiviral evaluation of 2-thioxo-benzo[g]quinazolin-4(3H)-one derivatives
por: Al-Salahi, Rashad, et al.
Publicado: (2016)

Synthesis of Novel 7-Substituted-5-phenyl-[1,2,4]triazolo[1,5-a] Pyrimidines with Anticonvulsant Activity
por: Jiang, Nan, et al.
Publicado: (2012)

Synthesis and biological evaluation of 4-(1H-1,2,4-triazol-1-yl)benzoic acid hybrids as anticancer agents
por: Abuelizz, Hatem A., et al.
Publicado: (2019)

The Structural and Optical Properties of 1,2,4-Triazolo[4,3-a]pyridine-3-amine
por: Dymińska, Lucyna, et al.
Publicado: (2022)

Pd-catalysed [3 + 3] annelations in the stereoselective synthesis of indolizidines
por: Provoost, Olivier Y, et al.
Publicado: (2007)

Synthesis and Biological Activity of 3-(2-Furanyl)-6-Aryl-1,2,4-Triazolo[3,4-b]-1,3,4 –Thiadiazoles
por: Zhang, Li-Xue, et al.
Publicado: (2002)

Synthesis and Antimicrobial Evaluation of Some New Thiazoline and Thiazolidinone Derivatives Incorporating [1,2,4]Triazolo[1,5-a]benzimidazole
por: Mahmoud, A. M., et al.
Publicado: (2013)

Synthesis of 5-Alkoxythieno[2,3-e][1,2,4]triazolo[4,3-c]pyrimidine Derivatives and Evaluation of Their Anticonvulsant Activities
por: Wang, Shi-Ben, et al.
Publicado: (2015)

2-Methyl-1,2,4-triazolo[4,3-a]pyridin-2-ium tetrafluoroborate
por: Wei, Siping, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_grb6eo4tvqbfshsvkqkhv6qn4u