Synthesis and Antioxidant Activity of Some New Coumarinyl-1,3-Thiazolidine-4-ones

A series of Schiff’s bases (E)-N-2-aryliden-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetohydrazides 2a-l and N-(2-(substituted phenyl)-4-oxo-thiazolidin-3-yl)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetamides 3a-l were synthesized and evaluated for their antioxidant activity by the phosphomolybdenum meth...

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Autores principales: Čačić, Milan, Molnar, Maja, Šarkanj, Bojan, Has-Schön, Elizabeta, Rajković, Valentina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259306/
https://www.ncbi.nlm.nih.gov/pubmed/20881932
http://dx.doi.org/10.3390/molecules15106795
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author Čačić, Milan
Molnar, Maja
Šarkanj, Bojan
Has-Schön, Elizabeta
Rajković, Valentina
author_facet Čačić, Milan
Molnar, Maja
Šarkanj, Bojan
Has-Schön, Elizabeta
Rajković, Valentina
author_sort Čačić, Milan
collection PubMed
description A series of Schiff’s bases (E)-N-2-aryliden-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetohydrazides 2a-l and N-(2-(substituted phenyl)-4-oxo-thiazolidin-3-yl)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetamides 3a-l were synthesized and evaluated for their antioxidant activity by the phosphomolybdenum method. Most of the Schiff’s bases and thiazolidine-4-ones bearing two hydroxyl groups on the phenyl ring showed excellent antioxidant activity in comparison with ascorbic acid. Preliminary investigation on cytotoxic and antifungal activity was done on some representative samples.
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spelling pubmed-62593062018-12-06 Synthesis and Antioxidant Activity of Some New Coumarinyl-1,3-Thiazolidine-4-ones Čačić, Milan Molnar, Maja Šarkanj, Bojan Has-Schön, Elizabeta Rajković, Valentina Molecules Article A series of Schiff’s bases (E)-N-2-aryliden-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetohydrazides 2a-l and N-(2-(substituted phenyl)-4-oxo-thiazolidin-3-yl)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetamides 3a-l were synthesized and evaluated for their antioxidant activity by the phosphomolybdenum method. Most of the Schiff’s bases and thiazolidine-4-ones bearing two hydroxyl groups on the phenyl ring showed excellent antioxidant activity in comparison with ascorbic acid. Preliminary investigation on cytotoxic and antifungal activity was done on some representative samples. MDPI 2010-09-29 /pmc/articles/PMC6259306/ /pubmed/20881932 http://dx.doi.org/10.3390/molecules15106795 Text en © 2010 by the authors; http://creativecommons.org/licenses/by/3.0/ licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Čačić, Milan
Molnar, Maja
Šarkanj, Bojan
Has-Schön, Elizabeta
Rajković, Valentina
Synthesis and Antioxidant Activity of Some New Coumarinyl-1,3-Thiazolidine-4-ones
title Synthesis and Antioxidant Activity of Some New Coumarinyl-1,3-Thiazolidine-4-ones
title_full Synthesis and Antioxidant Activity of Some New Coumarinyl-1,3-Thiazolidine-4-ones
title_fullStr Synthesis and Antioxidant Activity of Some New Coumarinyl-1,3-Thiazolidine-4-ones
title_full_unstemmed Synthesis and Antioxidant Activity of Some New Coumarinyl-1,3-Thiazolidine-4-ones
title_short Synthesis and Antioxidant Activity of Some New Coumarinyl-1,3-Thiazolidine-4-ones
title_sort synthesis and antioxidant activity of some new coumarinyl-1,3-thiazolidine-4-ones
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259306/
https://www.ncbi.nlm.nih.gov/pubmed/20881932
http://dx.doi.org/10.3390/molecules15106795
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AT hasschonelizabeta synthesisandantioxidantactivityofsomenewcoumarinyl13thiazolidine4ones
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