Concise Syntheses of Trifluoromethylated Cyclic and Acyclic Analogues of cADPR

A novel trifluoromethylated analogue of cADPR, 8-CF(3)-cIDPDE (5) was designed and synthesized via construction of N(1),N(9)-disubstituted hypoxanthine, trifluoromethylation and intramolecular condensation. A series of acyclic analogues of cADPR were also designed and synthesized. These compounds co...

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Detalles Bibliográficos
Autores principales: Huang, Xiangchen, Dong, Min, Liu, Jian, Zhang, Kehui, Yang, Zhenjun, Zhang, Liangren, Zhang, Lihe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259357/
https://www.ncbi.nlm.nih.gov/pubmed/21119564
http://dx.doi.org/10.3390/molecules15128689
Descripción
Sumario:A novel trifluoromethylated analogue of cADPR, 8-CF(3)-cIDPDE (5) was designed and synthesized via construction of N(1),N(9)-disubstituted hypoxanthine, trifluoromethylation and intramolecular condensation. A series of acyclic analogues of cADPR were also designed and synthesized. These compounds could be useful molecules for studying the structure-activity relationship of cADPR analogues and exploring the cADPR/RyR Ca(2+) signalling system.

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