Concise Syntheses of Trifluoromethylated Cyclic and Acyclic Analogues of cADPR

A novel trifluoromethylated analogue of cADPR, 8-CF(3)-cIDPDE (5) was designed and synthesized via construction of N(1),N(9)-disubstituted hypoxanthine, trifluoromethylation and intramolecular condensation. A series of acyclic analogues of cADPR were also designed and synthesized. These compounds co...

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Detalles Bibliográficos
Autores principales: Huang, Xiangchen, Dong, Min, Liu, Jian, Zhang, Kehui, Yang, Zhenjun, Zhang, Liangren, Zhang, Lihe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259357/
https://www.ncbi.nlm.nih.gov/pubmed/21119564
http://dx.doi.org/10.3390/molecules15128689
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author Huang, Xiangchen
Dong, Min
Liu, Jian
Zhang, Kehui
Yang, Zhenjun
Zhang, Liangren
Zhang, Lihe
author_facet Huang, Xiangchen
Dong, Min
Liu, Jian
Zhang, Kehui
Yang, Zhenjun
Zhang, Liangren
Zhang, Lihe
author_sort Huang, Xiangchen
collection PubMed
description A novel trifluoromethylated analogue of cADPR, 8-CF(3)-cIDPDE (5) was designed and synthesized via construction of N(1),N(9)-disubstituted hypoxanthine, trifluoromethylation and intramolecular condensation. A series of acyclic analogues of cADPR were also designed and synthesized. These compounds could be useful molecules for studying the structure-activity relationship of cADPR analogues and exploring the cADPR/RyR Ca(2+) signalling system.
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spelling pubmed-62593572018-12-06 Concise Syntheses of Trifluoromethylated Cyclic and Acyclic Analogues of cADPR Huang, Xiangchen Dong, Min Liu, Jian Zhang, Kehui Yang, Zhenjun Zhang, Liangren Zhang, Lihe Molecules Article A novel trifluoromethylated analogue of cADPR, 8-CF(3)-cIDPDE (5) was designed and synthesized via construction of N(1),N(9)-disubstituted hypoxanthine, trifluoromethylation and intramolecular condensation. A series of acyclic analogues of cADPR were also designed and synthesized. These compounds could be useful molecules for studying the structure-activity relationship of cADPR analogues and exploring the cADPR/RyR Ca(2+) signalling system. MDPI 2010-11-30 /pmc/articles/PMC6259357/ /pubmed/21119564 http://dx.doi.org/10.3390/molecules15128689 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/)
spellingShingle Article
Huang, Xiangchen
Dong, Min
Liu, Jian
Zhang, Kehui
Yang, Zhenjun
Zhang, Liangren
Zhang, Lihe
Concise Syntheses of Trifluoromethylated Cyclic and Acyclic Analogues of cADPR
title Concise Syntheses of Trifluoromethylated Cyclic and Acyclic Analogues of cADPR
title_full Concise Syntheses of Trifluoromethylated Cyclic and Acyclic Analogues of cADPR
title_fullStr Concise Syntheses of Trifluoromethylated Cyclic and Acyclic Analogues of cADPR
title_full_unstemmed Concise Syntheses of Trifluoromethylated Cyclic and Acyclic Analogues of cADPR
title_short Concise Syntheses of Trifluoromethylated Cyclic and Acyclic Analogues of cADPR
title_sort concise syntheses of trifluoromethylated cyclic and acyclic analogues of cadpr
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259357/
https://www.ncbi.nlm.nih.gov/pubmed/21119564
http://dx.doi.org/10.3390/molecules15128689
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AT zhangkehui concisesynthesesoftrifluoromethylatedcyclicandacyclicanaloguesofcadpr
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