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Rescue of four pediatric patients with severe influenza A (H3N2) in Weifang, China

In this report, we summarize our experience of rescuing four children with severe type A H3N2 influenza from January to February 2017 in Weifang People’s Hospital, Shandong Province, China for reference in clinical treatment. Two boys and two girls, ranging in age from 3 months to 6 years, with feve...

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Autores principales: Li, Tianhua, Qi, Ningning, Gao, Xiaona, Yu, Haili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259391/
https://www.ncbi.nlm.nih.gov/pubmed/30213216
http://dx.doi.org/10.1177/0300060518792795
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author Li, Tianhua
Qi, Ningning
Gao, Xiaona
Yu, Haili
author_facet Li, Tianhua
Qi, Ningning
Gao, Xiaona
Yu, Haili
author_sort Li, Tianhua
collection PubMed
description In this report, we summarize our experience of rescuing four children with severe type A H3N2 influenza from January to February 2017 in Weifang People’s Hospital, Shandong Province, China for reference in clinical treatment. Two boys and two girls, ranging in age from 3 months to 6 years, with fever, cough, and asthma, were admitted to the pediatric intensive care unit. All children had severe pulmonary infection with respiratory distress. Three children had myocardial damage, two had liver damage, and one had encephalitis. One child had a history of bronchial asthma and one had severe spinal muscular atrophy. After all four children were admitted to the pediatric intensive care unit, they were provided active and effective organ function support and ventilator-assisted respiration. They were treated with gamma globulin, methylprednisolone, and antibiotics. Three children were treated with anti-influenza drugs and recovered from influenza; one child died even before antiviral treatment intervention on the first day. Definite diagnosis of the cases was through clinical manifestations, supplemented by laboratory tests, such as influenza virus H3N2 rapid antigen detection and nucleic acid detection. Early antiviral therapy, high-dose glucocorticoids and immunoglobulins, and systemic comprehensive rescue might be important for rescuing children with severe influenza A (H3N2).
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spelling pubmed-62593912018-11-30 Rescue of four pediatric patients with severe influenza A (H3N2) in Weifang, China Li, Tianhua Qi, Ningning Gao, Xiaona Yu, Haili J Int Med Res Case Reports In this report, we summarize our experience of rescuing four children with severe type A H3N2 influenza from January to February 2017 in Weifang People’s Hospital, Shandong Province, China for reference in clinical treatment. Two boys and two girls, ranging in age from 3 months to 6 years, with fever, cough, and asthma, were admitted to the pediatric intensive care unit. All children had severe pulmonary infection with respiratory distress. Three children had myocardial damage, two had liver damage, and one had encephalitis. One child had a history of bronchial asthma and one had severe spinal muscular atrophy. After all four children were admitted to the pediatric intensive care unit, they were provided active and effective organ function support and ventilator-assisted respiration. They were treated with gamma globulin, methylprednisolone, and antibiotics. Three children were treated with anti-influenza drugs and recovered from influenza; one child died even before antiviral treatment intervention on the first day. Definite diagnosis of the cases was through clinical manifestations, supplemented by laboratory tests, such as influenza virus H3N2 rapid antigen detection and nucleic acid detection. Early antiviral therapy, high-dose glucocorticoids and immunoglobulins, and systemic comprehensive rescue might be important for rescuing children with severe influenza A (H3N2). SAGE Publications 2018-09-13 2018-11 /pmc/articles/PMC6259391/ /pubmed/30213216 http://dx.doi.org/10.1177/0300060518792795 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Reports
Li, Tianhua
Qi, Ningning
Gao, Xiaona
Yu, Haili
Rescue of four pediatric patients with severe influenza A (H3N2) in Weifang, China
title Rescue of four pediatric patients with severe influenza A (H3N2) in Weifang, China
title_full Rescue of four pediatric patients with severe influenza A (H3N2) in Weifang, China
title_fullStr Rescue of four pediatric patients with severe influenza A (H3N2) in Weifang, China
title_full_unstemmed Rescue of four pediatric patients with severe influenza A (H3N2) in Weifang, China
title_short Rescue of four pediatric patients with severe influenza A (H3N2) in Weifang, China
title_sort rescue of four pediatric patients with severe influenza a (h3n2) in weifang, china
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259391/
https://www.ncbi.nlm.nih.gov/pubmed/30213216
http://dx.doi.org/10.1177/0300060518792795
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