A New Xanthone from the Bark Extract of Rheedia acuminata and Antiplasmodial Activity of Its Major Compounds

Bioassay-guided fractionation of the ethyl acetate bark extract of Rheedia acuminata led to the isolation of the new compound 1,5,6-trihydroxy-3-methoxy-7-geranyl-xanthone (1), together with four known compounds 2-5. These compounds were tested in vitro for their antiplasmodial activity on a chloroq...

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Autores principales: Marti, Guillaume, Eparvier, Véronique, Litaudon, Marc, Grellier, Philippe, Guéritte, Françoise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259415/
https://www.ncbi.nlm.nih.gov/pubmed/20948498
http://dx.doi.org/10.3390/molecules15107106
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author Marti, Guillaume
Eparvier, Véronique
Litaudon, Marc
Grellier, Philippe
Guéritte, Françoise
author_facet Marti, Guillaume
Eparvier, Véronique
Litaudon, Marc
Grellier, Philippe
Guéritte, Françoise
author_sort Marti, Guillaume
collection PubMed
description Bioassay-guided fractionation of the ethyl acetate bark extract of Rheedia acuminata led to the isolation of the new compound 1,5,6-trihydroxy-3-methoxy-7-geranyl-xanthone (1), together with four known compounds 2-5. These compounds were tested in vitro for their antiplasmodial activity on a chloroquine-resistant strain of Plasmodium falciparum (FcB1) and for their cytotoxicity against the human diploid embryonic lung cell line MRC-5.
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spelling pubmed-62594152018-12-06 A New Xanthone from the Bark Extract of Rheedia acuminata and Antiplasmodial Activity of Its Major Compounds Marti, Guillaume Eparvier, Véronique Litaudon, Marc Grellier, Philippe Guéritte, Françoise Molecules Article Bioassay-guided fractionation of the ethyl acetate bark extract of Rheedia acuminata led to the isolation of the new compound 1,5,6-trihydroxy-3-methoxy-7-geranyl-xanthone (1), together with four known compounds 2-5. These compounds were tested in vitro for their antiplasmodial activity on a chloroquine-resistant strain of Plasmodium falciparum (FcB1) and for their cytotoxicity against the human diploid embryonic lung cell line MRC-5. MDPI 2010-10-14 /pmc/articles/PMC6259415/ /pubmed/20948498 http://dx.doi.org/10.3390/molecules15107106 Text en © 2010 by the authors; http://creativecommons.org/licenses/by/3.0/ licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Marti, Guillaume
Eparvier, Véronique
Litaudon, Marc
Grellier, Philippe
Guéritte, Françoise
A New Xanthone from the Bark Extract of Rheedia acuminata and Antiplasmodial Activity of Its Major Compounds
title A New Xanthone from the Bark Extract of Rheedia acuminata and Antiplasmodial Activity of Its Major Compounds
title_full A New Xanthone from the Bark Extract of Rheedia acuminata and Antiplasmodial Activity of Its Major Compounds
title_fullStr A New Xanthone from the Bark Extract of Rheedia acuminata and Antiplasmodial Activity of Its Major Compounds
title_full_unstemmed A New Xanthone from the Bark Extract of Rheedia acuminata and Antiplasmodial Activity of Its Major Compounds
title_short A New Xanthone from the Bark Extract of Rheedia acuminata and Antiplasmodial Activity of Its Major Compounds
title_sort new xanthone from the bark extract of rheedia acuminata and antiplasmodial activity of its major compounds
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259415/
https://www.ncbi.nlm.nih.gov/pubmed/20948498
http://dx.doi.org/10.3390/molecules15107106
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